6GZD Chain A
Casein kinase I isoform alpha (CSNK1A1)
Active — 99.9%DFG-inαC-inType1 · LCI
Resolution
2.28 Å
R-value
0.177
Predicted activity confidence99.9%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
AEFIVGGKYKLGRKIGSGSFGDIYLATNITNGEEVAVKLESQKARHPQLHYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKA
UniProt reference sequence
YKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRI
Aligned reference sequence
YKLV----------------RKIGSGS----------------FGDIYLAIN--IT------------------------------------NGEEVAVKLES--QKAR------------------------------HPQLLYESKLYKIL--Q-----------------------GGVGIPHIRWYGQEKD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YNVLVMDLLG---------------PSLEDLFNF--CSR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFTMKTVLMLADQMISRIEYVHTK---------------------------------------------NFIHRDI-----KPDNFLMGI--GRH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CNKLFLIDFGLAKKYRDNRTR--QHIPYRED--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNLTGTARYASINAHLG--------------------------------IEQS-RRDDMESLGYVLMYFNRT-----------------SLPWQG--LKAATKK-----------------------------------------QKYEKISEKKMST--PVEVLCKGFP-----------------------------------------------------------------------------------------------------AEFAMYLNYCRGLRFEEAPD--------------YMYLRQLFRI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YKLG----------------RKIGSGS----------------FGDIYLATN--IT------------------------------------NGEEVAVKLES--QKAR------------------------------HPQLHYESKLYKIL--Q-----------------------GGVGIPHIRWYGQEKD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YNVLVMDLLG---------------PSLEDLFNF--CSR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFTMKTVLMLADQMISRIEYVHTK---------------------------------------------NFIHRDI-----KPDNFLMGI--GRH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CNKLFLIDFGLAKKYRDNRTR--QHIPYRED--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNLTGTARYASINAHLG--------------------------------IEQS-RRDDMESLGYVLMYFNRT-----------------SLPWQG--LKAATKK-----------------------------------------QKYEKISEKKMST--PVEVLCKGFP-----------------------------------------------------------------------------------------------------AEFAMYLNYCRGLRFEEAPD--------------YMYLRQLFRI
Activation segment
DFGLAKKYRDNRTR--QHIPYRED--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNLTGTARYASIN
Binding pocket
RKIGSGSFGDIYLVAVKLEQLHYESKLYKILQVGIPHIRWYVLVMDLLG_PSLEDLFNFYVHTKNFIHRDIKPDNFLMLIDFGLA
Ligand info
Orthosteric ligand
LCI
Allosteric ligand
TCE
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6GZD, Chain A