6GU7 Chain C
Cyclin-dependent kinase 1 (CDK1)
Inactive — 0.1%DFG-inαC-out
Resolution
2.75 Å
R-value
0.229
Predicted activity confidence0.1%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD
UniProt reference sequence
YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
Aligned reference sequence
YTKI----------------EKIGEGT----------------YGVVYKGRH--KT------------------------------------TGQVVAMKKIR--LESEEEGV--------------------------PSTAIREISLLKEL--------------------------RHPNIVSLQDVLMQDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLYLIFEFLS---------------MDLKKYLDS--IPPGQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSR---------------------------------------------RVLHRDL-----KPQNLLIDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGTIKLADFGLARAFGIPIRV--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THEVVTLWYRSPEVLLG--S-----------------------------ARYS-TPVDIWSIGTIFAELATK-----------------KPLFHG--------------------------------------------------DSEIDQLFRIFRA--LGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLD-------------------------------------------------------------------------ENGLDLLSKMLIYDPAKRIS--------------GKMALNHPYF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YTKI----------------EKIGEGT----------------YGVVYKGRH--KT------------------------------------TGQVVAMKKIR--LESEEEGV--------------------------PSTAIREISLLKEL--------------------------RHPNIVSLQDVLMQDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLYLIFEFLS---------------MDLKKYLDS--IPPGQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSR---------------------------------------------RVLHRDL-----KPQNLLIDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGTIKLADFGLARAFGIPIRV--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THEVVTLWYRSPEVLLG--S-----------------------------ARYS-TPVDIWSIGTIFAELATK-----------------KPLFHG--------------------------------------------------DSEIDQLFRIFRA--LGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLD-------------------------------------------------------------------------ENGLDLLSKMLIYDPAKRIS--------------GKMALNHPYF
Activation segment
DFGLARAFGIPIRV--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THEVVTLWYRSPE
Binding pocket
EKIGEGTYGVVYKVAMKKITAIREISLLKELRPNIVSLQDVYLIFEFLS_MDLKKYLDSFCHSRRVLHRDLKPQNLLILADFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6GU7, Chain C