6GR9 Chain A
Aurora kinase C (AURKC)
Active — 99.8%DFG-inαC-inType1 · VX6
Resolution
2.25 Å
R-value
0.184
Predicted activity confidence99.8%
Structure info
Alternate conformationA
Missing atoms2
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
RLVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSDKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPCA
UniProt reference sequence
FEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWV
Aligned reference sequence
FEIG----------------RPLGKGK----------------FGNVYLARL--KE------------------------------------SHFIVALKVLF--KSQIEKEGL-------------------------EHQLRREIEIQAHL--------------------------QHPNILRLYNYFHDAR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVYLILEYAPR--------------GELYKELQK--SE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLDEQRTATIIEELADALTYCHDK---------------------------------------------KVIHRDI-----KPENLLLGF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGEVKIADFGWSVHTPSLRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTMCGTLDYLPPEMIEG--------------------------------RTYD-EKVDLWCIGVLCYELLVG-----------------YPPFES--------------------------------------------------ASHSETYRRILKV--DVRFPLSMP------------------------------------------------------------------------------------------------------LGARDLISRLLRYQPLERLP--------------LAQILKHPWV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FEIG----------------RPLGKGK----------------FGNVYLARL--KE------------------------------------SHFIVALKVLF--KSQIEKEGL-------------------------EHQLRREIEIQAHL--------------------------QHPNILRLYNYFHDAR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVYLILEYAPR--------------GELYKELQK--SD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLDEQRTATIIEELADALTYCHDK---------------------------------------------KVIHRDI-----KPENLLLGF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGEVKIADFGWSVHTPSLRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-MCGTLDYLPPEMIEG--------------------------------RTYD-EKVDLWCIGVLCYELLVG-----------------YPPFES--------------------------------------------------ASHSETYRRILKV--DVRFPLSMP------------------------------------------------------------------------------------------------------LGARDLISRLLRYQPLERLP--------------LAQILKHPWV
Activation segment
DFGWSVHTPSLRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-MCGTLDYLPPE
Binding pocket
RPLGKGKFGNVYLVALKVLQLRREIEIQAHLQPNILRLYNYYLILEYAPRGELYKELQKYCHDKKVIHRDIKPENLLLIADFGWS
Ligand info
Orthosteric ligand
VX6
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6GR9, Chain A