6GQL Chain A
Mast/stem cell growth factor receptor Kit (KIT)
Inactive — 0.1%DFG-outαC-inType2 · F8B
Resolution
2.01 Å
R-value
0.202
Predicted activity confidence0.1%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
YSYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSNYVDKGNARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQIVQDIEKQISES
UniProt reference sequence
LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEK
Aligned reference sequence
LSFG----------------KTLGAGA----------------FGKVVEATA--YGLIKSD-------------------------------AAMTVAVKMLK--PSAHLTE---------------------------REALMSELKVLSYL--G-----------------------NHMNIVNLLGACTIGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTLVITEYCCY--------------GDLLNFLRR--KRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDEL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALDLEDLLSFSYQVAKGMAFLASK---------------------------------------------NCIHRDL-----AARNILLTH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRITKICDFGLARDIKNDSNY--VVK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNARLPVKWMAPESIFN--------------------------------CVYT-FESDVWSYGIFLWELFSL--G--------------SSPYPG--M-----------------------------------------------PVDSKFYKMIKEG--FRMLSPEHAP-----------------------------------------------------------------------------------------------------AEMYDIMKTCWDADPLKRPT--------------FKQIVQLIEK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LSFG----------------KTLGAGA----------------FGKVVEATA--QGLIKSD-------------------------------AAMTVAVKMLK--PSAHSTE---------------------------REALMSELKVLSYL--G-----------------------NHENIVNLLGACTHGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTLVITEYCCY--------------GDLLNFLRR--KRDEF---------VPYLYK---------------------------------------------------------D---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLTLEHLLSFSYQVAKGMAFLASK---------------------------------------------NCIHRDL-----AARNILLTH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNITKICDFGLARDIKNDSNY--VDK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNARLPVKWMAPESIFN--------------------------------SVYT-FESDVWSYGIFLWELFSL--G--------------SSPYPG--M-----------------------------------------------PVDSKFYKMIKEG--FRMSSPEYAP-----------------------------------------------------------------------------------------------------AEMYDIMKTCWDADPDKRPT--------------FKQIVQDIEK
Activation segment
DFGLARDIKNDSNY--VDK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNARLPVKWMAPE
Binding pocket
KTLGAGAFGKVVEVAVKMLALMSELKVLSYLGENIVNLLGALVITEYCCYGDLLNFLRRFLASKNCIHRDLAARNILLICDFGLA
Ligand info
Orthosteric ligand
F8B
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6GQL, Chain A