6GLA Chain B
Tyrosine-protein kinase JAK3 (JAK3)
Inactive — 11.5%DFG-inαC-inType1 · F4B
Resolution
1.92 Å
R-value
0.228
Predicted activity confidence11.5%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
DPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRALAARNILVESEAHVKIADFGLAKLLPLDKDYYVVRQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMERDVPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSR
UniProt reference sequence
LEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNS
Aligned reference sequence
LEWH----------------ENLGHGS----------------FTKIYRGCR--HEVVDGEA------------------------------RKTEVLLKVMD--AKHKNC----------------------------MESFLEAASLMSQV--------------------------SYRHLVLLHGVCMAG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSTMVQEFVHL--------------GAIDMYLRK--RGH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVPASWKLQVVKQLAYALNYLEDK---------------------------------------------GLPHGNV-----SARKVLLAR--EGADGS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPFIKLSDPGVSPAVLSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMLTDRIPWVAPECLRE--A-----------------------------QTLS-LEADKWGFGATVWEVFSG--V--------------TMPISA--------------------------------------------------LDPAKKLQFYEDR--QQLPAPKW-------------------------------------------------------------------------------------------------------TELALLIQQCMAYEPVQRPS--------------FRAVIRDLNS
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LKYI----------------SQLGKGN----------------F-GSVELCR-----YDPLG------------------------------DNTGALVAVKQ--LQHFQR----------------------------EIQILKALHSDFIV--------------------------KYRGVSYGPG---RQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLRLVMEYLPS--------------GCLRDFLQR--HRA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLDASRLLLYSSQICKGMEYL------------------------------------------------------G-----SRRCVLAAR--NILVES------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EAHVKIADFG--LAKL-L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLDKDPIFWYAPESL-S--D-----------------------------NIFS-RQSDVWSFGVVLYELFTY--C--------------DKSCSA--------------------------------------------------L--SRLLELLEEG--QRLPAPCP-------------------------------------------------------------------------------------------------------AEVHELMKLCWAPSPQDRPS--------------FSALGPQLSR
Activation segment
DFG--LAKL-L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLDKDPIFWYAPE
Binding pocket
SQLGKGNFGSVELVAVKQLDFQREIQILKALHDFIVKYRGVRLVMEYLPSGCLRDFLQRYLGSRRCVHRALAARNILVIADFGLA
Ligand info
Orthosteric ligand
F4B
Allosteric ligand
PHU
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6GLA, Chain B