6GDM Chain A
Mitogen-activated protein kinase 1 (MAPK1)
Active — 99.9%DFG-outαC-inType1.5_Front · F3Z
Resolution
1.91 Å
R-value
0.185
Predicted activity confidence99.9%
Structure info
Alternate conformationB
Missing atoms0
Missing residues1
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
GAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTDLKIDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDDLPKEKLKELIFEETARFQP
UniProt reference sequence
YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL
Aligned reference sequence
YTNL----------------SYIGEGA----------------YGMVCSAYD--NV------------------------------------NKVRVAIKKIS--PFEHQTY---------------------------CQRTLREIKILLRF--------------------------RHENIIGINDIIRAPT--IEQMK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVYIVQDLME---------------TDLYKLLKT--Q--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLSNDHICYFLYQILRGLKYIHSA---------------------------------------------NVLHRDL-----KPSNLLLNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TCDLKICDFGLARVADPDHDH--TGFL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEYVATRWYRAPEIMLN--S-----------------------------KGYT-KSIDIWSVGCILAEMLSN-----------------RPIFPG--------------------------------------------------KHYLDQLNHILGI--LGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNAD-----------------------------------------------------------------------SKALDLLDKMLTFNPHKRIE--------------VEQALAHPYL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YTNL----------------SYIGEGA----------------YGMVCSAYD--NV------------------------------------NKVRVAIKKIS--PFEHQTY----------------------------QRTLREIKILLRF--------------------------RHENIIGINDIIRAPT--IEQMK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVYIVQDLME---------------TDLYKLLKT--Q--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLSNDHICYFLYQILRGLKYIHSA---------------------------------------------NVLHRDL-----KPSNLLLNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-DLKI-DFGLARVADPDHDH--TGFL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEYVATRWYRAPEIMLN--S-----------------------------KGYT-KSIDIWSVGCILAEMLSN-----------------RPIFPG--------------------------------------------------KHYLDQLNHILGI--LGSPSQEDLN-IINLKARNYLLSLPHKNKVPWNRLFPNAD-----------------------------------------------------------------------SKALDLLDKMLTFNPHKRIE--------------VEQALAHPYL
Activation segment
DFGLARVADPDHDH--TGFL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEYVATRWYRAPE
Binding pocket
SYIGEGAYGMVCSVAIKKIRTLREIKILLRFRENIIGINDIYIVQDLME_TDLYKLLKTYIHSANVLHRDLKPSNLLLI_DFGLA
Ligand info
Orthosteric ligand
F3Z
Allosteric ligand
None
Ligand typeType1.5_Front
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6GDM, Chain A