6G78 Chain A
Ribosomal protein S6 kinase alpha-6 (RPS6KA6)
Inactive — 0.1%DFG-outαC-outATPlike · ANP
Resolution
2.5 Å
R-value
0.227
Predicted activity confidence0.1%
Structure info
Alternate conformation—
Missing atoms6
Missing residues6
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
VVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKP
UniProt reference sequence
FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFF
Aligned reference sequence
FELL----------------KVLGQGS----------------FGKVFLVRK--KTGPD---------------------------------AGQLYAMKVLK--KASLKVRD--------------------------RVRTKMERDILVEV--------------------------NHPFIVKLHYAFQTEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLYLILDFLRG--------------GDVFTRLSK--EV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LFTEEDVKFYLAELALALDHLHQL---------------------------------------------GIVYRDL-----KPENILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IGHIKLTDFGLSKESVDQEKK--A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YSFCGTVEYMAPEVVNR--------------------------------RGHS-QSADWWSYGVLMFEMLTG-----------------TLPFQG--------------------------------------------------KDRNETMNMILKA--KLGMPQFLS------------------------------------------------------------------------------------------------------AEAQSLLRMLFKRNPANRLG--SEG---------VEEIKRHLFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FELL----------------KVLGQGS----------------FGKVFLVRK--KTGPD---------------------------------AGQLYAMKVLK--KASLKVRD----------------------------------DILVEV--------------------------NHPFIVKLHYAFQTEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLYLILDFLRG--------------GDVFTRLSK--EV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LFTEEDVKFYLAELALALDHLHQL---------------------------------------------GIVYRDL-----KPENILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IGHIKLTDFGLSKESVDQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTVEYMAPEVVNR--------------------------------RGHS-QSADWWSYGVLMFEMLTG-----------------TLPFQG--------------------------------------------------KDRNETMNMILKA--KLGMPQFLS------------------------------------------------------------------------------------------------------AEAQSLLRMLFKRNPANRLG--SEG---------VEEIKRHLFF
Activation segment
DFGLSKESVDQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTVEYMAPE
Binding pocket
KVLGQGSFGKVFLYAMKVL______DILVEVNPFIVKLHYAYLILDFLRGGDVFTRLSKHLHQLGIVYRDLKPENILLLTDFGLS
Ligand info
Orthosteric ligand
ANP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6G78, Chain A