6G4Z Chain A
Mitogen-activated protein kinase kinase kinase 14 (MAP3K14)
Active — 92.1%DFG-inαC-inType1.5_Back · ELW
Resolution
2.84 Å
R-value
0.237
Predicted activity confidence92.1%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
PVEEYLVHALQGSVSSGQAHSLASLAKTWSDNEGVLLTEKLKPVDYEYREEVHWMTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVEELVACAGLSSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQSLLTGDYIPGTETHMAPEVVMGKPCDAKVDIWSSCCMMLHMLNGCHPWTQYFRGPLCLKIASEPPPIREIPPSCAPLTAQAIQEGLRKEPVHRASAMELRRKVGKALQEVGGLKSPWKGEYKEPR
UniProt reference sequence
WATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNR
Aligned reference sequence
WATH--Q-------------LRLGRGS----------------FGEVHRMED--KQ------------------------------------TGFQCAVKKVR--L---------------------------------EVFRAEELMACAGL--------------------------TSPRIVPLYGAVREGP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WVNIFMELLEG--------------GSLGQLVKE--QG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CLPEDRALYYLGQALEGLEYLHSR---------------------------------------------RILHGDV-----KADNVLLSS--D-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSHAALCDFGHAVCLQPDGLG--KSLLTG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DYIPGTETHMAPEVVLG--------------------------------RSCD-AKVDVWSSCCMMLHMLNG-----------------CHPWTQ--------------------------------------------------FFRGPLCLKIASE--PPPVREIPPSCA---------------------------------------------------------------------------------------------------PLTAQAIQEGLRKEPIHRVS--------------AAELGGKVNR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
WMTH--Q-------------PRVGRGS----------------FGEVHRMKD--KQ------------------------------------TGFQCAVKKVR--L---------------------------------EVFRVEELVACAGL--------------------------SSPRIVPLYGAVREGP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WVNIFMELLEG--------------GSLGQLIKQ--MG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CLPEDRALYYLGQALEGLEYLHTR---------------------------------------------RILHGDV-----KADNVLLSS--D-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSRAALCDFGHALCLQ--------SLLTG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DYIPGTETHMAPEVVMG--------------------------------KPCD-AKVDIWSSCCMMLHMLNG-----------------CHPWTQ--------------------------------------------------YFRGPLCLKIASE--PPPIREIPPSCA---------------------------------------------------------------------------------------------------PLTAQAIQEGLRKEPVHRAS--------------AMELRRKVPR
Activation segment
DFGHALCLQ--------SLLTG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DYIPGTETHMAPE
Binding pocket
PRVGRGSFGEVHRCAVKKVFRVEELVACAGLSPRIVPLYGANIFMELLEGGSLGQLIKQYLHTRRILHGDVKADNVLLLCDFGHA
Ligand info
Orthosteric ligand
ELW
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6G4Z, Chain A