6FYV Chain A
Dual specificity protein kinase CLK4 (CLK4)
Active — 98.6%DFG-inαC-inType1 · 3NG
Resolution
2.46 Å
R-value
0.204
Predicted activity confidence98.6%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
ICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLK
UniProt reference sequence
YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF
Aligned reference sequence
YEIV----------------DTLGEGA----------------FGKVVECID--HGM-----------------------------------DGMHVAVKIVK--NVGRY-----------------------------REAARSEIQVLEHL--NSTDPN------------------SVFRCVQMLEWFDHHG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVCIVFELLG---------------LSTYDFIKE--NSFL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFQIDHIRQMAYQICQSINFLHHN---------------------------------------------KLTHTDL-----KPENILFVK--SDYVVKYNSKMKRDERTLK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTDIKVVDFGSATYDDEHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STLVSTRHYRAPEVILA--------------------------------LGWS-QPCDVWSIGCILIEYYLG-----------------FTVFQT--------------------------------------------------HDSKEHLAMMERI--LGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEH----------------------------------------------------------EKLFDLVRRMLEYDPTQRIT--------------LDEALQHPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEIV----------------DTLGEGA----------------FGKVVECID--HGM-----------------------------------DGMHVAVKIVK--NVGRY-----------------------------REAARSEIQVLEHL--NSTDPN------------------SVFRCVQMLEWFDHHG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVCIVFELLG---------------LSTYDFIKE--NSFL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFQIDHIRQMAYQICQSINFLHHN---------------------------------------------KLTHTDL-----KPENILFVK--SDYVVKYN---KRDERTLK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTDIKVVDFGSATYDDEHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STLVSTRHYRAPEVILA--------------------------------LGWS-QPCDVWSIGCILIEYYLG-----------------FTVFQT--------------------------------------------------HDSKEHLAMMERI--LGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEH----------------------------------------------------------EKLFDLVRRMLEYDPTQRIT--------------LDEALQHPFF
Activation segment
DFGSATYDDEHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STLVSTRHYRAPE
Binding pocket
DTLGEGAFGKVVEVAVKIVAARSEIQVLEHLNFRCVQMLEWCIVFELLG_LSTYDFIKEFLHHNKLTHTDLKPENILFVVDFGSA
Ligand info
Orthosteric ligand
3NG
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6FYV, Chain A