6FNI Chain A
Ephrin type-B receptor 4 (EPHB4)
Inactive — 0.4%DFG-outαC-inType2 · DXH
Resolution
1.47 Å
R-value
0.224
Predicted activity confidence0.4%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
AKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQIVSALDKMIRNPASLKIVAR
UniProt reference sequence
VKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDK
Aligned reference sequence
VKIE----------------EVIGAGE----------------FGEVCRGRL--KAPGK---------------------------------KESCVAIKTLK--GGYTERQ---------------------------RREFLSEASIMGQF--------------------------EHPNIIRLEGVVTNSM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMILTEFMEN--------------GALDSFLRL--NDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIASGMRYLAEM---------------------------------------------SYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRFLEENSSD--PTYTSS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGGKIPIRWTAPEAIAF--------------------------------RKFT-SASDAWSYGIVMWEVMSF--G--------------ERPYWD--------------------------------------------------MSNQDVINAIEQD--YRLPPPPDCP-----------------------------------------------------------------------------------------------------TSLHQLMLDCWQKDRNARPR--------------FPQVVSALDK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
VKIE----------------EVIGAGE----------------FGEVCRGRL--KAPGK---------------------------------KESCVAIKTL-------ERQ---------------------------RREFLSEASIMGQF--------------------------EHPNIIRLEGVVTNSM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMILTEFMEN--------------GALDSFLRL--NDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIASGMRYLAEM---------------------------------------------SYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPIRWTAPEAIAF--------------------------------RKFT-SASDVWSYGIVMWEVMSF--G--------------ERPYWD--------------------------------------------------MSNQDVINAIEQD--YRLPPPPDCP-----------------------------------------------------------------------------------------------------TSLHQLMLDCWQKDRNARPR--------------FPQIVSALDK
Activation segment
DFGLSRF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPIRWTAPE
Binding pocket
EVIGAGEFGEVCRVAIKTLEFLSEASIMGQFEPNIIRLEGVMILTEFMENGALDSFLRLYLAEMSYVHRDLAARNILVVSDFGLS
Ligand info
Orthosteric ligand
DXH
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6FNI, Chain A