6FIO Chain A
Epithelial discoidin domain-containing receptor 1 (DDR1)
Inactive — 0.4%DFG-outαC-outType2 · DJH
Resolution
1.99 Å
R-value
0.217
Predicted activity confidence0.4%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
DGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGADPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNT
UniProt reference sequence
LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAE
Aligned reference sequence
LRFK----------------EKLGEGQ----------------FGEVHLCEV--DSPQDLVSLDFPLNVRKG--------------------HPLLVAVKILR--PDATKNA---------------------------RNDFLKEVKIMSRL--------------------------KDPNIIRLLGVCVQDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLCMITDYMEN--------------GDLNQFLSA--HQLEDKAAEGAPGDGQAAQGP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TISYPMLLHVAAQIASGMRYLATL---------------------------------------------NFVHRDL-----ATRNCLVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NFTIKIADFGMSRNLYAGDYY--RVQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRAVLPIRWMAWECILM--------------------------------GKFT-TASDVWAFGVTLWEVLML--CR-------------AQPFGQ--------------------------------------------------LTDEQVIENAGEF--FRDQGRQVYLSRPPACP----------------------------------------------------------------------------------------------QGLYELMLRCWSRESEQRPP--------------FSQLHRFLAE
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LRFK----------------EKLGEGQ----------------FGEVHLCEV--DSPQDLVSLDFPLNVRKG--------------------HPLLVAVKILR--PDATKNA---------------------------RNDFLKEVKIMSRL--------------------------KDPNIIRLLGVCVQDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLCMITDYMEN--------------GDLNQFLSA--HQLEDKAAEGA--------DP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TISYPMLLHVAAQIASGMRYLATL---------------------------------------------NFVHRDL-----ATRNCLVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NFTIKIADFGMSRNLYAGDYY--RVQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRAVLPIRWMAWECILM--------------------------------GKFT-TASDVWAFGVTLWEVLML--CR-------------AQPFGQ--------------------------------------------------LTDEQVIENAGEF--FRDQGRQVYLSRPPACP----------------------------------------------------------------------------------------------QGLYELMLRCWSRESEQRPP--------------FSQLHRFLAE
Activation segment
DFGMSRNLYAGDYY--RVQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRAVLPIRWMAWE
Binding pocket
EKLGEGQFGEVHLVAVKILDFLKEVKIMSRLKPNIIRLLGVCMITDYMENGDLNQFLSAYLATLNFVHRDLATRNCLVIADFGMS
Ligand info
Orthosteric ligand
DJH
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6FIO, Chain A