6FER Chain K
Discoidin domain-containing receptor 2 (DDR2)
Inactive — 0.0%DFG-outαC-outType2 · D6Q
Resolution
2.87 Å
R-value
0.204
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
VEEFPRKLLTFKEKLGEGQFGEVHLCEVPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHETVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLLLQ
UniProt reference sequence
LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLLLQ
Aligned reference sequence
LTFK----------------EKLGEGQ----------------FGEVHLCEV--EGMEKFKDKDFALDVSAN--------------------QPVLVAVKMLR--ADANKNA---------------------------RNDFLKEIKIMSRL--------------------------KDPNIIHLLAVCITDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLCMITEYMEN--------------GDLNQFLSR--HEPPNSSSSDVR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVSYTNLKFMATQIASGMKYLSSL---------------------------------------------NFVHRDL-----ATRNCLVGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYTIKIADFGMSRNLYSGDYY--RIQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRAVLPIRWMSWESILL--------------------------------GKFT-TASDVWAFGVTLWETFTF--CQ-------------EQPYSQ--------------------------------------------------LSDEQVIENTGEF--FRDQGRQTYLPQPAICP----------------------------------------------------------------------------------------------DSVYKLMLSCWRRDTKNRPS--------------FQEIHLLLLQ
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LTFK----------------EKLGEGQ----------------FGEVHLCEV-----------------------------------------PVLVAVKMLR--ADANKNA---------------------------RNDFLKEIKIMSRL--------------------------KDPNIIHLLAVCITDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLCMITEYMEN--------------GDLNQFLSR--HE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVSYTNLKFMATQIASGMKYLSSL---------------------------------------------NFVHRDL-----ATRNCLVGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYTIKIADFGMSRNLYSGDYY--RIQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRAVLPIRWMSWESILL--------------------------------GKFT-TASDVWAFGVTLWETFTF--CQ-------------EQPYSQ--------------------------------------------------LSDEQVIENTGEF--FRDQGRQTYLPQPAICP----------------------------------------------------------------------------------------------DSVYKLMLSCWRRDTKNRPS--------------FQEIHLLLLQ
Activation segment
DFGMSRNLYSGDYY--RIQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRAVLPIRWMSWE
Binding pocket
EKLGEGQFGEVHLVAVKMLDFLKEIKIMSRLKPNIIHLLAVCMITEYMENGDLNQFLSRYLSSLNFVHRDLATRNCLVIADFGMS
Ligand info
Orthosteric ligand
D6Q
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6FER, Chain K