6FDZ Chain U
Serine/threonine-protein kinase ULK3 (ULK3)
Active — 59.0%DFG-outαC-outType1 · C87
Resolution
2.55 Å
R-value
0.234
Predicted activity confidence59.0%
Structure info
Alternate conformation—
Missing atoms21
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
PPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEH
UniProt reference sequence
FILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWV
Aligned reference sequence
FILT----------------ERLGSGT----------------YATVYKAYA--KKD-----------------------------------TREVVAIKCVA--KKSLNKAS--------------------------VENLLTEIEILKGI--------------------------RHPHIVQLKDFQWDSD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIYLIMEFCAG--------------GDLSRFIHT--RR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILPEKVARVFMQQLASALQFLHER---------------------------------------------NISHLDL-----KPQNILLSS--LE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPHLKLADFGFAQHMSPWDEK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVLRGSPLYMAPEMVCQ--------------------------------RQYD-ARVDLWSMGVILYEALFG-----------------QPPFAS--------------------------------------------------RSFSELEEKIRSN--RVIELPLRPLLS---------------------------------------------------------------------------------------------------RDCRDLLQRLLERDPSRRIS--------------FQDFFAHPWV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FILT----------------ERLGSGT----------------YATVYKAYA--KKD-----------------------------------TREVVAIKCVA--KKSLNKAS--------------------------VENLLTEIEILKGI--------------------------RHPHIVQLKDFQWDSD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIYLIMEFCAG--------------GDLSRFIHT--RR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILPEKVARVFMQQLASALQFLHER---------------------------------------------NISHLDL-----KPQNILLSS--LE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPHLKLADFGFAQHMSPWDEK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVLRGSPLYMAPEMVC----------------------------------QYD-ARVDLWSMGVILYEALFG-----------------QPPFAS--------------------------------------------------RSFSELEEKIRSN--RVIELPLRPLLS---------------------------------------------------------------------------------------------------RDCRDLLQRLLERDPSRRIS--------------FQDFFAHPWV
Activation segment
DFGFAQHMSPWDEK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVLRGSPLYMAPE
Binding pocket
ERLGSGTYATVYKVAIKCVNLLTEIEILKGIRPHIVQLKDFYLIMEFCAGGDLSRFIHTFLHERNISHLDLKPQNILLLADFGFA
Ligand info
Orthosteric ligand
C87
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6FDZ, Chain U