6FDY Chain U
Serine/threonine-protein kinase ULK3 (ULK3)
Active — 94.5%DFG-inαC-inType1,Allosteric · DB8
Resolution
1.7 Å
R-value
0.207
Predicted activity confidence94.5%
Structure info
Alternate conformation—
Missing atoms21
Missing residues4
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
PRLDGFILTERLGATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEH
UniProt reference sequence
FILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWV
Aligned reference sequence
FILT----------------ERLGSGT----------------YATVYKAYA--KKD-----------------------------------TREVVAIKCVA--KKSLNKAS--------------------------VENLLTEIEILKGI--------------------------RHPHIVQLKDFQWDSD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIYLIMEFCAG--------------GDLSRFIHT--RR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILPEKVARVFMQQLASALQFLHER---------------------------------------------NISHLDL-----KPQNILLSS--LE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPHLKLADFGFAQHMSPWDEK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVLRGSPLYMAPEMVCQ--------------------------------RQYD-ARVDLWSMGVILYEALFG-----------------QPPFAS--------------------------------------------------RSFSELEEKIRSN--RVIELPLRPLLS---------------------------------------------------------------------------------------------------RDCRDLLQRLLERDPSRRIS--------------FQDFFAHPWV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FILT----------------ERLG--------------------ATVYKAYA--KKD-----------------------------------TREVVAIKCVA--KKSLNKAS--------------------------VENLLTEIEILKGI--------------------------RHPHIVQLKDFQWDSD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIYLIMEFCAG--------------GDLSRFIHT--RR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILPEKVARVFMQQLASALQFLHER---------------------------------------------NISHLDL-----KPQNILLSS--LE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPHLKLADFGFAQHMSPWDEK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVLRGSPLYMAPEMVCQ--------------------------------RQYD-ARVDLWSMGVILYEALFG-----------------QPPFAS--------------------------------------------------RSFSELEEKIRSN--RVIELPLRPLLS---------------------------------------------------------------------------------------------------RDCRDLLQRLLERDPSRRIS--------------FQDFFAHPWV
Activation segment
DFGFAQHMSPWDEK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVLRGSPLYMAPE
Binding pocket
ERLG____ATVYKVAIKCVNLLTEIEILKGIRPHIVQLKDFYLIMEFCAGGDLSRFIHTFLHERNISHLDLKPQNILLLADFGFA
Ligand info
Orthosteric ligand
DB8
Allosteric ligand
DB8
Ligand typeType1,Allosteric
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6FDY, Chain U