6FD3 Chain A
Serine/threonine-protein kinase PAK 3 (PAK3)
Active — 99.7%DFG-inαC-inATPlike · ADP
Resolution
1.52 Å
R-value
0.176
Predicted activity confidence99.7%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
SMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLDKPLSSLTPLIIAAKEAIKN
UniProt reference sequence
YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL
Aligned reference sequence
YTRF----------------EKIGQGA----------------SGTVYTALD--IA------------------------------------TGQEVAIKQMN--LQQQPK----------------------------KELIINEILVMREN--------------------------KNPNIVNYLDSYLVGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELWVVMEYLAG--------------GSLTDVVTE--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CMDEGQIAAVCRECLQALDFLHSN---------------------------------------------QVIHRDI-----KSDNILLGM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGSVKLTDFGFCAQITPEQSK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STMVGTPYWMAPEVVTR--------------------------------KAYG-PKVDIWSLGIMAIEMVEG-----------------EPPYLN--------------------------------------------------ENPLRALYLIATN--GTPELQNPERLS---------------------------------------------------------------------------------------------------AVFRDFLNRCLEMDVDRRGS--------------AKELLQHPFL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YTRF----------------EKIGQGA----------------SGTVYTALD--IA------------------------------------TGQEVAIKQMN--LQQQPK----------------------------KELIINEILVMREN--------------------------KNPNIVNYLDSYLVGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELWVVMEYLAG--------------GSLTDVVTE--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CMDEGQIAAVCRECLQALDFLHSN---------------------------------------------QVIHRDI-----KSDNILLGM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGSVKLTDFGFCAQITPEQSK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-MVGTPYWMAPEVVTR--------------------------------KAYG-PKVDIWSLGIMAIEMVEG-----------------EPPYLN--------------------------------------------------ENPLRALYLIATN--GTPELQNPERLS---------------------------------------------------------------------------------------------------AVFRDFLNRCLEMDVDRRGS--------------AKELLQHPFL
Activation segment
DFGFCAQITPEQSK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-MVGTPYWMAPE
Binding pocket
EKIGQGASGTVYTVAIKQMLIINEILVMRENKPNIVNYLDSWVVMEYLAGGSLTDVVTEFLHSNQVIHRDIKSDNILLLTDFGFC
Ligand info
Orthosteric ligand
ADP
Allosteric ligand
T8L
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6FD3, Chain A