6ES0 Chain B
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)
Inactive — 0.0%DFG-outαC-inType2 · BW8
Resolution
2.38 Å
R-value
0.216
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms7
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQ
UniProt reference sequence
LADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEP
Aligned reference sequence
LADL----------------RYLSRGA----------------SGTVSSARH--AD------------------------------------WRVQVAVKHLH--IHTPLLDSE-------------------------RKDVLREAEILHKA--------------------------RFSYILPILGICNEPE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLGIVTEYMPN--------------GSLNELLHR--KTEYP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVAWPLRFRILHEIALGVNYLHNM--TP-----------------------------------------PLLHHDL-----KTQNILLDN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFHVKIADFGLSKWRMMSLSQ--SRSSKS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APEGGTIIYMPPENYEP--GQK---------------------------SRAS-IKHDIYSYAVITWEVLSR-----------------KQPFED--V-----------------------------------------------TNPLQIMYSVSQG--HRPVINEESLPYDIPHR----------------------------------------------------------------------------------------------ARMISLIESGWAQNPDERPS--------------FLKCLIELEP
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LADL----------------RYLSRGA----------------SGTVSSARH--AD------------------------------------WRVQVAVKHL----------SE-------------------------RKDVLREAEILHKA--------------------------RFSYILPILGICNEPE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLGIVTEYMPN--------------GSLNELLHR--KTEYP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVAWPLRFRILHEIALGVNYLHNM--TP-----------------------------------------PLLHHDL-----KTQNILLDN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFHVKIADFGLSKWR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTIIYMPPENYEP--GQK---------------------------SRAS-IKHDIYSYAVITWEVLSR-----------------KQPFED--V-----------------------------------------------TNPLQIMYSVSQG--HRPVINEESLPYDIPHR----------------------------------------------------------------------------------------------ARMISLIESGWAQNPDERPS--------------FLKCLIELEP
Activation segment
DFGLSKWR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTIIYMPPE
Binding pocket
RYLSRGASGTVSSVAVKHLDVLREAEILHKARSYILPILGIGIVTEYMPNGSLNELLHRHNMTPPLLHHDLKTQNILLIADFGLS
Ligand info
Orthosteric ligand
BW8
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6ES0, Chain B