6ELR Chain A
Tyrosine-protein kinase JAK1 (JAK1)
Active — 94.2%DFG-inαC-inType1 · BFK
Resolution
1.8 Å
R-value
0.182
Predicted activity confidence94.2%
Structure info
Alternate conformationA
Missing atoms11
Missing residues3
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
DIVSEKKPATEVDPTHFEKRFLKRIRDLGEGKVELCRYDPEGDNTGEQVAVKSLKHIADLKKEIEILRNLYHENIVKYKGICTENGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKETVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
UniProt reference sequence
LVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINK
Aligned reference sequence
LVQG----------------EHLGRGT----------------RTHIYSGTL--MDYKDDEGTSEE--------------------------KKIKVILKVLD--PSHRDI----------------------------SLAFFEAASMMRQV--------------------------SHKHIVYLYGVCVRDV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ENIMVEEFVEG--------------GPLDLFMHR--KSD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLTTPWKFKVAKQLASALSYLEDK---------------------------------------------DLVHGNV-----CTKNLLLAR--EGIDSEC-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GPFIKLSDPGIPITVLSR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QECIERIPWIAPECVED--S-----------------------------KNLS-VAADKWSFGTTLWEICYN--G--------------EIPLKD--------------------------------------------------KTLIEKERFYESR--CRPVTPSC-------------------------------------------------------------------------------------------------------KELADLMTRCMNYDPNQRPF--------------FRAIMRDINK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
DIVS----------------EPATEVD----------------PTHFEKRFL--KRIRDLEG---------------------------------KVELCRYD--PSLKHI----------------------------ADLKKE-IEILRNL--------------------------YHENIVKYKGIC---T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ENIM--EFLPS--------------GSLKEYLPK--NKN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KINLKQQLKYAVQICKGMDYLGSR---------------------------------------------QYVH------------RDLAA--RNVLVES-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EHQVKIGDFGLTKAIETD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KERDSPVFWYAPECLMQ--S-----------------------------K-FY-IASDVWSFGVTLHEYCDS--D--------------SSPLKV--------------------------------------------------NTLKEGKR--------LPCPPNC-------------------------------------------------------------------------------------------------------PEVYQLMRKCWEFQPSNRTS--------------FIEGFEALLK
Activation segment
DFGLTKAIETD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KERDSPVFWYAPE
Binding pocket
RDLGE___GKVELVAVKSLDLKKEIEILRNLYENIVKYKGIKLIMEFLPSGSLKEYLPKYLGSRQYVHRDLAARNVLVIGDFGLT
Ligand info
Orthosteric ligand
BFK
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6ELR, Chain A