6EIF Chain A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)
Active — 99.4%DFG-inαC-inType1 · B5T
Resolution
2.22 Å
R-value
0.22
Predicted activity confidence99.4%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
KVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDEYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK
UniProt reference sequence
YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF
Aligned reference sequence
YEID----------------SLIGKGS----------------FGQVVKAYD--RV------------------------------------EQEWVAIKIIK--NKKAF-----------------------------LNQAQIEVRLLELM--NKHDTE------------------MKYYIVHLKRHFMFRN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLCLVFEMLS---------------YNLYDLLRN--TNFR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVSLNLTRKFAQQMCTALLFLATP--EL-----------------------------------------SIIHCDL-----KPENILLCN--PK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSAIKIVDFGSSCQLGQRI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YQYIQSRFYRSPEVLLG--------------------------------MPYD-LAIDMWSLGCILVEMHTG-----------------EPLFSG--------------------------------------------------ANEVDQMNKIVEV--LGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADY--------------------------------------LKFKDLILRMLDYDPKTRIQ--------------PYYALQHSFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEID----------------SLIGKGS----------------FGQVVKAYD--RV------------------------------------EQEWVAIKIIK--NKKAF-----------------------------LNQAQIEVRLLELM--NKHDTE------------------MKYYIVHLKRHFMFRN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLCLVFEMLS---------------YNLYDLLRN--TNFR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVSLNLTRKFAQQMCTALLFLATP--EL-----------------------------------------SIIHCDL-----KPENILLCN--PK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSAIKIVDFGSSCQLGQRI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YQ-IQSRFYRSPEVLLG--------------------------------MPYD-LAIDMWSLGCILVEMHTG-----------------EPLFSG--------------------------------------------------ANEVDQMNKIVEV--LGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKD---EYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADY--------------------------------------LKFKDLILRMLDYDPKTRIQ--------------PYYALQHSFF
Activation segment
DFGSSCQLGQRI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YQ-IQSRFYRSPE
Binding pocket
SLIGKGSFGQVVKVAIKIIQAQIEVRLLELMNYYIVHLKRHCLVFEMLS_YNLYDLLRNATPELSIIHCDLKPENILLIVDFGSS
Ligand info
Orthosteric ligand
B5T
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6EIF, Chain A