6EGD Chain A
Interleukin-1 receptor-associated kinase 4 (IRAK4)
Inactive — 21.8%DFG-inαC-inType1 · J87
Resolution
2.1 Å
R-value
0.184
Predicted activity confidence21.8%
Structure info
Alternate conformationA
Missing atoms0
Missing residues2
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
FHSFSFYELKNVTNNFDERPISVGGNKMGEGGVVYKGYVNNTTVAVKKLATTEELKQQFDQEIKVMAKCQHENLVELLGFSSDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRNIKSANILLDEAFTAKISDFGLARATAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT
UniProt reference sequence
NVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQE
Aligned reference sequence
NVT---NNFDERPISVGG--NKMGEGG----------------FGVVYKGYV----------------------------------------NNTTVAVKKLA--AMVDITTEEL------------------------KQQFDQEIKVMAKC--------------------------QHENLVELLGFSSDGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLCLVYVYMPN--------------GSLLDRLSC--LDGTP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHEN---------------------------------------------HHIHRDI-----KSANILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AFTAKISDFGLARASEKFAQT--VMT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRIVGTTAYMAPEALR---------------------------------GEIT-PKSDIYSFGVVLLEIITG-----------------LPAVDE--HREP--------------------------------------------QLLLDIKEEIEDE--EKTIEDYIDKKMNDADSTSV-------------------------------------------------------------------------------------------EAMYSVASQCLHEKKNKRPD--------------IKKVQQLLQE
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
NVT---NNFDERPISVGG--NKMGEG------------------GVVYKGYV----------------------------------------NNTTVAVKKLA-------TTEEL------------------------KQQFDQEIKVMAKC--------------------------QHENLVELLGFSS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLCLVYVYMPN--------------GSLLDRLSC--LDGTP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHEN---------------------------------------------HHIHRNI-----KSANILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AFTAKISDFGLARA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAYMAPEALR---------------------------------GEIT-PKSDIYSFGVVLLEIITG-----------------LPAVDE--HREP--------------------------------------------QLLLDIKEEIEDE--EKTIEDYIDKKMNDADSTSV-------------------------------------------------------------------------------------------EAMYSVASQCLHEKKNKRPD--------------IKKVQQLLQE
Activation segment
DFGLARA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAYMAPE
Binding pocket
NKMGEG__GVVYKVAVKKLQFDQEIKVMAKCQENLVELLGFCLVYVYMPNGSLLDRLSCFLHENHHIHRNIKSANILLISDFGLA
Ligand info
Orthosteric ligand
J87
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6EGD, Chain A