6DC0 Chain A
Tribbles homolog 1 (TRIB1)
Active — 99.3%DFG-inαC-in
Resolution
2.8 Å
R-value
0.223
Predicted activity confidence99.3%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-na
Sequence info
PDB sequence
PSRIADYLLLPLAEREHVSRALCIHTGRELRCKVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVEHETSIDISAY
UniProt reference sequence
YLLLPLAEREHVSRALCIHTGRELRCKVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWF
Aligned reference sequence
YLLL----------------PLA------ERE-------------HVSRALC--IH------------------------------------TGRELRCKVFP--IKHY------------------------------QDKIRPYIQLPSHS-----------------------------NITGIVEVILGET--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KAYVFFEKDF---------------GDMHSYVRS--RK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLREEEAARLFKQIVSAVAHCHQS---------------------------------------------AIVLGDL-----KLRKFVFST--EE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTQLRLESLEDTHIMKGEDDA--L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDKHGCPAYVSPEILNT--T-----------------------------GTYSGKAADVWSLGVMLYTLLVG-----------------RYPFHD--------------------------------------------------SDPSALFSKIRRG--QFCIPEHIS------------------------------------------------------------------------------------------------------PKARCLIRSLLRREPSERLT--------------APEILLHPWF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YLLL----------------PLA------ERE-------------HVSRALC--IH------------------------------------TGRELRCKVFP--IKHY------------------------------QDKIRPYIQLPSHS-----------------------------NITGIVEVILGET--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KAYVFFEKDF---------------GDMHSYVRS--RK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLREEEAARLFKQIVSAVAHCHQS---------------------------------------------AIVLGDL-----KLRKFVFST--EE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTQLRLESLEDTHIMKGEDDA--L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDKHGCPAYVSPEILNT--T-----------------------------GTYSGKAADVWSLGVMLYTLLVG-----------------RYPFHD--------------------------------------------------SDPSALFSKIRRG--QFCIPEHIS------------------------------------------------------------------------------------------------------PKARCLIRSLLRREPSERLT--------------APEILLHPWF
Activation segment
SLEDTHIMKGEDDA--L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDKHGCPAYVSPE
Binding pocket
LLLPLAEREHVSRLRCKVFYQDKIRPYIQLPSSNITGIVEVYVFFEKDF_GDMHSYVRSHCHQSAIVLGDLKLRKFVFLRLESLE
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6DC0, Chain A