6D3L Chain A
Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2)
Inactive — 4.1%DFG-inαC-in
Resolution
3.1 Å
R-value
0.263
Predicted activity confidence4.1%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
TVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKK
UniProt reference sequence
FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTV
Aligned reference sequence
FKEI----------------ELIGSGG----------------FGQVFKAKH--RI------------------------------------DGKTYVIKRVK--YN--------------------------------NEKAEREVKALAKL--------------------------DHVNIVHYNGCWDGFD--YDPETSDDSLESSDYDPENSKNSSRSKTK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CLFIQMEFCDK--------------GTLEQWIEK--RRGE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLDKVLALELFEQITKGVDYIHSK---------------------------------------------KLIHRDL-----KPSNIFLVD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TKQVKIGDFGLVTSLKNDGKR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRSKGTLRYMSPEQISS--------------------------------QDYG-KEVDLYALGLILAELLHV-------------------------CDTA--------------------------------------------FETSKFFTDLRDG--IISDIFD--------------------------------------------------------------------------------------------------------KKEKTLLQKLLSKKPEDRPN--------------TSEILRTLTV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FKEI----------------ELIGSGG----------------FGQVFKAKH--RI------------------------------------DGKTYVIKRVK--YN--------------------------------NEKAEREVKALAKL--------------------------DHVNIVHYNGCWDGFD--YDPET-------------------RSKTK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CLFIQMEFCDK--------------GTLEQWIEK--RRGE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLDKVLALELFEQITKGVDYIHSK---------------------------------------------KLIHRDL-----KPSNIFLVD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TKQVKIGDFGLVTSL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEQISS--------------------------------QDYG-KEVDLYALGLILAELLHV-------------------------CDTA--------------------------------------------FETSKFFTDLRDG--IISDIFD--------------------------------------------------------------------------------------------------------KKEKTLLQKLLSKKPEDRPN--------------TSEILRTLTV
Activation segment
DFGLVTSL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PE
Binding pocket
ELIGSGGFGQVFKYVIKRVKAEREVKALAKLDVNIVHYNGCFIQMEFCDKGTLEQWIEKYIHSKKLIHRDLKPSNIFLIGDFGLV
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6D3L, Chain A