6D3K Chain B
Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2)
Inactive — 0.2%DFG-inαC-inATPlike · ADP
Resolution
2.6 Å
R-value
0.212
Predicted activity confidence0.2%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
TKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKK
UniProt reference sequence
FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTV
Aligned reference sequence
FKEI----------------ELIGSGG----------------FGQVFKAKH--RI------------------------------------DGKTYVIKRVK--YN--------------------------------NEKAEREVKALAKL--------------------------DHVNIVHYNGCWDGFD--YDPETSDDSLESSDYDPENSKNSSRSKTK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CLFIQMEFCDK--------------GTLEQWIEK--RRGE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLDKVLALELFEQITKGVDYIHSK---------------------------------------------KLIHRDL-----KPSNIFLVD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TKQVKIGDFGLVTSLKNDGKR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRSKGTLRYMSPEQISS--------------------------------QDYG-KEVDLYALGLILAELLHV-------------------------CDTA--------------------------------------------FETSKFFTDLRDG--IISDIFD--------------------------------------------------------------------------------------------------------KKEKTLLQKLLSKKPEDRPN--------------TSEILRTLTV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FKEI----------------ELIGSGG----------------FGQVFKAKH--RI------------------------------------DGKTYVIKRVK--YN--------------------------------NEKAEREVKALAKL--------------------------DHVNIVHYNGCWDGFD--YD----------------------RSKTK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CLFIQMEFCDK--------------GTLEQWIEK--RRGE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLDKVLALELFEQITKGVDYIHSK---------------------------------------------KLIHRDL-----KPSNIFLVD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TKQVKIGDFGLVTSL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLRYMSPEQISS--------------------------------QDYG-KEVDLYALGLILAELLHV-------------------------CDTA--------------------------------------------FETSKFFTDLRDG--IISDIFD--------------------------------------------------------------------------------------------------------KKEKTLLQKLLSKKPEDRPN--------------TSEILRTLTV
Activation segment
DFGLVTSL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLRYMSPE
Binding pocket
ELIGSGGFGQVFKYVIKRVKAEREVKALAKLDVNIVHYNGCFIQMEFCDKGTLEQWIEKYIHSKKLIHRDLKPSNIFLIGDFGLV
Ligand info
Orthosteric ligand
ADP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6D3K, Chain B