6CZ4 Chain A
Protein-tyrosine kinase 6 (PTK6)
Inactive — 9.1%DFG-outαC-outType2 · FKY
Resolution
0.0 Å
R-value
0.203
Predicted activity confidence9.1%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
DAERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSS
UniProt reference sequence
FTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSS
Aligned reference sequence
FTLC----------------RKLGSGY----------------FGEVFEGLW--K-------------------------------------DRVQVAIKVIS--RDNLLH----------------------------QQMLQSEIQAMKKL--------------------------RHKHILALYAVVSVGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVYIITELMAK--------------GSLLELLRD--SDEK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLPVSELLDIAWQVAEGMCYLESQ---------------------------------------------NYIHRDL-----AARNILVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTLCKVGDFGLARLIKEDVYL--S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HDHNIPYKWTAPEALSR--------------------------------GHYS-TKSDVWSFGILLHEMFSR--G--------------QVPYPG--------------------------------------------------MSNHEAFLRVDAG--YRMPCPLECP-----------------------------------------------------------------------------------------------------PSVHKLMLTCWCRDPEQRPC--------------FKALRERLSS
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FTLC----------------RKLGSGY----------------FGEVFEGLW--K-------------------------------------DRVQVAIKVIS--RDNLLH----------------------------QQMLQSEIQAMKKL--------------------------RHKHILALYAVVSVGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVYIITELMAK--------------GSLLELLRD--SDEK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLPVSELLDIAWQVAEGMCYLESQ---------------------------------------------NYIHRDL-----AARNILVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTLCKVGDFGLARLIKEDVYL--S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H----PYKWTAPEALSR--------------------------------GHYS-TKSDVWSFGILLHEMFSR--G--------------QVPYPG--------------------------------------------------MSNHEAFLRVDAG--YRMPCPLECP-----------------------------------------------------------------------------------------------------PSVHKLMLTCWCRDPEQRPC--------------FKALRERLSS
Activation segment
DFGLARLIKEDVYL--S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H----PYKWTAPE
Binding pocket
RKLGSGYFGEVFEVAIKVIMLQSEIQAMKKLRKHILALYAVYIITELMAKGSLLELLRDYLESQNYIHRDLAARNILVVGDFGLA
Ligand info
Orthosteric ligand
FKY
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6CZ4, Chain A