6CJ5 Chain A
MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2)
Inactive — 0.0%DFG-inαC-inType1 · F4G
Resolution
2.8 Å
R-value
0.207
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues2
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
GSTDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCCGACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGC
UniProt reference sequence
YQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWV
Aligned reference sequence
YQLQ--E-------------DVLGEGA----------------HARVQTCIN--LI------------------------------------TSQEYAVKIIE--KQPGHI----------------------------RSRVFREVEMLYQC--Q-----------------------GHRNVLELIEFFEEED--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFYLVFEKMRG--------------GSILSHIHK--RR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HFNELEASVVVQDVASALDFLHNK---------------------------------------------GIAHRDL-----KPENILCEH--PNQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VSPVKICDFDLGSGIKLNGDC--SPISTPEL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTPCGSAEYMAPEVVEA--FSEEA-------------------------SIYD-KRCDLWSLGVILYILLSG-----------------YPPFVG--RCGSDCGWDRGEACP---------------------------------ACQNMLFESIQEG--KYEFPDKDWAHIS--------------------------------------------------------------------------------------------------CAAKDLISKLLVRDAKQRLS--------------AAQVLQHPWV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YQLQ--E-------------DVLGEGA----------------HARVQTCIN--LI------------------------------------TSQEYAVKIIE--KQPGHI----------------------------RSRVFREVEMLYQC--Q-----------------------GHRNVLELIEFFEEED--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFYLVFEKMRG--------------GSILSHIHK--RR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HFNELEASVVVQDVASALDFLHNK---------------------------------------------GIAHRDL-----KPENILCEH--PNQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VSPVKICDF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGSAEYMAPEVVEA--FSEEA-------------------------SIYD-KRCDLWSLGVILYILLSG-----------------YPPFVG--RC---CG-----ACP---------------------------------ACQNMLFESIQEG--KYEFPDKDWAHIS--------------------------------------------------------------------------------------------------CAAKDLISKLLVRDAKQRLS--------------AAQVLQHPWV
Activation segment
DF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGSAEYMAPE
Binding pocket
DVLGEGAHARVQTYAVKIIRVFREVEMLYQCQRNVLELIEFYLVFEKMRGGSILSHIHKFLHNKGIAHRDLKPENILCICDF__G
Ligand info
Orthosteric ligand
F4G
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6CJ5, Chain A