6CD6 Chain C
Calcium/calmodulin-dependent protein kinase kinase 1 (CAMKK1)
Active — 100.0%DFG-outαC-inType1 · DXV
Resolution
2.2 Å
R-value
0.235
Predicted activity confidence100.0%
Structure info
Alternate conformationB
Missing atoms19
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
QLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTK
UniProt reference sequence
YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWV
Aligned reference sequence
YKLQ----------------SEIGKGA----------------YGVVRLAYN--ES------------------------------------EDRHYAMKVLS--KKKLLKQYGFPRRPPPRGSQAAQGGPAKQLLP--LERVYQEIAILKKL--------------------------DHVNVVKLIEVLDDPA--ED----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLYLVFDLLRK--------------GPVMEVPCD--K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFSEEQARLYLRDVILGLEYLHCQ---------------------------------------------KIVHRDI-----KPSNLLLGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGHVKIADFGVSNQFEGNDAQ--L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSTAGTPAFMAPEAISD--SG----------------------------QSFSGKALDVWATGVTLYCFVYG-----------------KCPFID--------------------------------------------------DFILALHRKIKNE--PVVFPEEPEIS----------------------------------------------------------------------------------------------------EELKDLILKMLDKNPETRIG--------------VPDIKLHPWV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YKLQ----------------SEIGKGA----------------YGVVRLAYN--ES------------------------------------EDRHYAMKVLS--KKKLL----------------------KQLLP--LERVYQEIAILKKL--------------------------DHVNVVKLIEVLDDPA--ED----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLYLVFDLLRK--------------GPVMEVPCD--K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFSEEQARLYLRDVILGLEYLHCQ---------------------------------------------KIVHRDI-----KPSNLLLGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGHVKIADFGVSNQFEGNDAQ--L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSTAGTPAFMAPEAIS---SG----------------------------QSFSGKALDVWATGVTLYCFVYG-----------------KCPFID--------------------------------------------------DFILALHRKIKNE--PVVFPEEPEIS----------------------------------------------------------------------------------------------------EELKDLILKMLDKNPETRIG--------------VPDIKLHPWV
Activation segment
DFGVSNQFEGNDAQ--L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSTAGTPAFMAPE
Binding pocket
QSEIGKGAYGVVRHYAMKVERVYQEIAILKKLHVNVVKLIENLYLVFDLRKGPVMEVPCEYLHCQKIVHRDIKPSNLLKIADFGV
Ligand info
Orthosteric ligand
DXV
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6CD6, Chain C