6C7Y Chain A
Tyrosine-protein kinase JAK1 (JAK1)
Active — 87.5%DFG-inαC-inATPlike · ADP
Resolution
2.5 Å
R-value
0.21
Predicted activity confidence87.5%
Structure info
Alternate conformationB
Missing atoms20
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
AHFEKRFLKRIRDLGEGHFGKVELCRYGDNTGEQVAVKSLKPHIADLKKEIEILRNLYHENIVKYKGICTEGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALL
UniProt reference sequence
LVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINK
Aligned reference sequence
LVQG----------------EHLGRGT----------------RTHIYSGTL--MDYKDDEGTSEE--------------------------KKIKVILKVLD--PSHRDI----------------------------SLAFFEAASMMRQV--------------------------SHKHIVYLYGVCVRDV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ENIMVEEFVEG--------------GPLDLFMHR--KSD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLTTPWKFKVAKQLASALSYLEDK---------------------------------------------DLVHGNV-----CTKNLLLAR--EGIDSEC-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GPFIKLSDPGIPITVLSR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QECIERIPWIAPECVED--S-----------------------------KNLS-VAADKWSFGTTLWEICYN--G--------------EIPLKD--------------------------------------------------KTLIEKERFYESR--CRPVTPSC-------------------------------------------------------------------------------------------------------KELADLMTRCMNYDPNQRPF--------------FRAIMRDINK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LKRI----------------RDLGEG-------------------HFGKVEL--CRYGDNTG--------------------------------EQVAVKSLK--PHIAD--------------------------------LKKEIEILRNL--------------------------YHENIVKYKGICTEGI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLIM--EFLPS--------------GSLKEYLPK--NKN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KINLKQQLKYAVQICKGMDYLGSR---------------------------------------------QYVH------------RDLAA--RNVLVES-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EHQVKIGDFGLTKAIETD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KERDSPVFWYAPECLMQ--S-----------------------------K-FY-IASDVWSFGVTLHEYCDS--D--------------SSPLKV--------------------------------------------------NTLKEGKR--------LPCPPNC-------------------------------------------------------------------------------------------------------PEVYQLMRKCWEFQPSNRTS--------------FLIEGFEALL
Activation segment
DFGLTKAIETD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KERDSPVFWYAPE
Binding pocket
RDLGEGHFGKVELVAVKSLDLKKEIEILRNLYENIVKYKGIKLIMEFLPSGSLKEYLPKYLGSRQYVHRDLAARNVLVIGDFGLT
Ligand info
Orthosteric ligand
ADP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6C7Y, Chain A