6C2Y Chain A
Beta-adrenergic receptor kinase 1 (GRK2)
Active — 72.3%DFG-inαC-inType1 · EJS
Resolution
2.74 Å
R-value
0.247
Predicted activity confidence72.3%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
KKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLACSHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKQLGEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKP
UniProt reference sequence
FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF
Aligned reference sequence
FSVH----------------RIIGRGG----------------FGEVYGCRK--AD------------------------------------TGKMYAMKCLD--KKRIKMKQG-------------------------ETLALNERIMLSLV--STG---------------------DCPFIVCMSYAFHTPD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLSFILDLMNG--------------GDLHYHLSQ--HG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VFSEADMRFYAAEIILGLEHMHNR---------------------------------------------FVVYRDL-----KPANILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HGHVRISDLGLACDFSKKKP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HASVGTHGYMAPEVLQK--G-----------------------------VAYD-SSADWFSLGCMLFKLLRG-----------------HSPFRQ--HKT---------------------------------------------KDKHEIDRMTLTM--AVELPDSFS------------------------------------------------------------------------------------------------------PELRSLLEGLLQRDVNRRLG--CLGRG-------AQEVKESPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FSVH----------------RIIGRGG----------------FGEVYGCRK--AD------------------------------------TGKMYAMKCLD--KKRIKMKQG-------------------------ETLALNERIMLSLV--STG---------------------DCPFIVCMSYAFHTPD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLSFILDLMNG--------------GDLHYHLSQ--HG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VFSEADMRFYAAEIILGLEHMHNR---------------------------------------------FVVYRDL-----KPANILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HGHVRISDLGLACDFSKKKP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HASVGTHGYMAPEVLQK--G-----------------------------VAYD-SSADWFSLGCMLFKLLRG-----------------HSPFRQ--HKT---------------------------------------------KDKHEIDRMTL----AVELPDSFS------------------------------------------------------------------------------------------------------PELRSLLEGLLQRDVNRRLG--CLGRG-------AQEVKESPFF
Activation segment
DLGLACDFSKKKP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HASVGTHGYMAPE
Binding pocket
RIIGRGGFGEVYGYAMKCLLALNERIMLSLVSPFIVCMSYASFILDLMNGGDLHYHLSQHMHNRFVVYRDLKPANILLISDLGLA
Ligand info
Orthosteric ligand
EJS
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6C2Y, Chain A