6BXI Chain B
Serine/threonine-protein kinase 38 (STK38)
Inactive — 0.0%DFG-outαC-outATPlike · ANP
Resolution
2.2 Å
R-value
0.173
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms4
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
RLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFP
UniProt reference sequence
FESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAPGVEEIKSNSFF
Aligned reference sequence
FESL----------------KVIGRGA----------------FGEVRLVQK--KD------------------------------------TGHVYAMKILR--KADMLEKEQ-------------------------VGHIRAERDILVEA--------------------------DSLWVVKMFYSFQDKL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLYLIMEFLPG--------------GDMMTLLMK--KD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLTEEETQFYIAETVLAIDSIHQL---------------------------------------------GFIHRDI-----KPDNLLLDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGHVKLSDFGLCTGLKKAHRT--EFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FSTVGTPDYIAPEVFMQ--------------------------------TGYN-KLCDWWSLGVIMYEMLIG-----------------YPPFCS--------------------------------------------------ETPQETYKKVMNW--KETLTFPPEVPIS--------------------------------------------------------------------------------------------------EKAKDLILRFCC-EWEHRIG--APG---------VEEIKSNSFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FESL----------------KVIGRGA----------------FGEVRLVQK--KD------------------------------------TGHVYAMKILR--KADMLEKEQ-------------------------VGHIRAERDILVEA--------------------------DSLWVVKMFYSFQDKL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLYLIMEFLPG--------------GDMMTLLMK--KD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLTEEETQFYIAETVLAIDSIHQL---------------------------------------------GFIHRDI-----KPDNLLLDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGHVKLSDFGLCTGLKKAHRT--EFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FSTVGTPDYIAPEVFMQ--------------------------------TGYN-KLCDWWSLGVIMYEMLIG-----------------YPPFCS--------------------------------------------------ETPQETYKKVMNW--KETLTFPPEVPIS--------------------------------------------------------------------------------------------------EKAKDLILRFCC-EWEHRIG--APG---------VEEIKSNSFF
Activation segment
DFGLCTGLKKAHRT--EFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FSTVGTPDYIAPE
Binding pocket
KVIGRGAFGEVRLYAMKILHIRAERDILVEADLWVVKMFYSYLIMEFLPGGDMMTLLMKSIHQLGFIHRDIKPDNLLLLSDFGLC
Ligand info
Orthosteric ligand
ANP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6BXI, Chain B