6BLN Chain A
Tyrosine-protein kinase BTK (BTK)
Active — 55.3%DFG-inαC-outType1 · DY4
Resolution
1.3 Å
R-value
0.157
Predicted activity confidence55.3%
Structure info
Alternate conformationA
Missing atoms8
Missing residues1
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEN
UniProt reference sequence
LTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILD
Aligned reference sequence
LTFL----------------KELGTGQ----------------FGVVKYGKW--R-------------------------------------GQYDVAIKMIK--EGSMS-----------------------------EDEFIEEAKVMMNL--------------------------SHEKLVQLYGVCTKQR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIFIITEYMAN--------------GCLLNYLRE--MRH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFQTQQLLEMCKDVCEAMEYLESK---------------------------------------------QFLHRDL-----AARNCLVND--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGVVKVSDFGLSRYVLDDEYT--SS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGSKFPVRWSPPEVLMY--------------------------------SKFS-SKSDIWAFGVLMWEIYSL--G--------------KMPYER--------------------------------------------------FTNSETAEHIAQG--LRLYRPHLAS-----------------------------------------------------------------------------------------------------EKVYTIMYSCWHEKADERPT--------------FKILLSNILD
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LTFL----------------KELGTGQ----------------FGVVKYGKW--R-------------------------------------GQYDVAIKMIK--EGSMS-----------------------------EDEFIEEAKVMMNL--------------------------SHEKLVQLYGVCTKQR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIFIITEYMAN--------------G-LLNYLRE--MRH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFQTQQLLEMCKDVCEAMEYLESK---------------------------------------------QFLHRDL-----AARNCLVND--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGVVKVSDFGLSRYVLDDEYT--SS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGSKFPVRWSPPEVLMY--------------------------------SKFS-SKSDIWAFGVLMWEIYSL--G--------------KMPYER--------------------------------------------------FTNSETAEHIAQG--LRLYRPHLAS-----------------------------------------------------------------------------------------------------EKVYTIMYSCWHEKADERPT--------------FKILLSNILD
Activation segment
DFGLSRYVLDDEYT--SS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGSKFPVRWSPPE
Binding pocket
KELGTGQFGVVKYVAIKMIEFIEEAKVMMNLSEKLVQLYGVFIITEYMANG_LLNYLREYLESKQFLHRDLAARNCLVVSDFGLS
Ligand info
Orthosteric ligand
DY4
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6BLN, Chain A