6BHC Chain A
Inactive tyrosine-protein kinase PEAK1 (PEAK1)
Inactive — 22.2%DFG-inαC-out
Resolution
2.3 Å
R-value
0.196
Predicted activity confidence22.2%
Structure info
Alternate conformationA
Missing atoms0
Missing residues27
Salt bridge (KinCore)Saltbr-na
Sequence info
PDB sequence
EVVGKIRSLHTDALKKLAVKCEDLFMAGQKDQLRFGVDSWSDFRLTSDKPCCEAGDAVYYTASYAKDPLNNYAVKICKSHSLAVRQSLAVHFNIQQDCGHFLAEVPNRLLPWEDKQRSHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLLVHYQPTRLIVSNFSQAKQKRDQSRLAPEIITAKKCDEFQTGILIYEMLHLPNPFDENPELKEREYTRADLPRIPFRSPYSRGLQQLASCLLNPNPSERILISDAKGILQCLLWGPREDLFQTFTACPSLVQRNTLLQNWLDIKRTLLMIKFAEKSLDGISLEDWLCAQYLAFATTDSLSCIVKILL
UniProt reference sequence
FRLTSDKPCCEAGDAVYYTASYAKDPLNNYAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPNRLLPWEDPDDPEKDEDDMEETEEDAKGETDGKNPKPCSEAASSQKENQGVMSKKQRSHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLLVHYQPGGTAQGFGPAEPSPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQSRLAPEIITATQYKKCDEFQTGILIYEMLHLPNPFDENPELKEREYTRADLPRIPFRSPYSRGLQQLASCLLNPNPSERILISDAKGILQC
Aligned reference sequence
FRLT--SD------------KPCCEAG----------------DAVYYTASY--AKD-----------------------------------PLNNYAVKICK--SKAKE-----------------------------SQQYYHSLAVRQSL--A-----------------------VHFNIQQDCGHFLAEV--PNRLLPWEDPDDPEKDEDDMEETEEDAKGETDGKNPKPCSEAASSQKENQGVMSKKQRS-------------------------------------------------------------------------------------------------------------------------------------------------------------------HVVVITREVPC--------------LTVADFVRD--SLAQHGKSPDL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YERQVCLLLLQLCSGLEHLKPY---------------------------------------------HVTHCDL-----RLENLLLVH--YQPGGTAQGFGPAEPSPTSSY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTRLIVSNFSQAKQKSHLVD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEILRDQSRLAPEIITA---------------------------------TQY-KKCDEFQTGILIYEMLHL-----------------PNPFDE-----------------------------------------------------------------NPELKEREYTRADLPRIPFRSPYS---------------------------------------------------------------------------------------RGLQQLASCLLNPNPSERIL--------------ISDAKGILQC
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FRLT--SD------------KPCCEAG----------------DAVYYTASY--AKD-----------------------------------PLNNYAVKICK--S--------------------------------------HSLAVRQSL--A-----------------------VHFNIQQDCGHFLAEV--PNRLLPWED----------------------------------------------KQRS-------------------------------------------------------------------------------------------------------------------------------------------------------------------HVVVITREVPC--------------LTVADFVRD--SLAQHGKSPDL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YERQVCLLLLQLCSGLEHLKPY---------------------------------------------HVTHCDL-----RLENLLLVH--YQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTRLIVSNFSQAKQK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDQSRLAPEIITA-------------------------------------KKCDEFQTGILIYEMLHL-----------------PNPFDE-----------------------------------------------------------------NPELKEREYTRADLPRIPFRSPYS---------------------------------------------------------------------------------------RGLQQLASCLLNPNPSERIL--------------ISDAKGILQC
Activation segment
NFSQAKQK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDQSRLAPE
Binding pocket
KPCCEAGDAVYYTYAVKIC_____S____HSLFNIQQDCGH__________________HLKPYHVTHCDLRLENLLLVSNFSQA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6BHC, Chain A