6BFN Chain A
Interleukin-1 receptor-associated kinase 1 (IRAK1)
Inactive — 32.9%DFG-inαC-inType1 · DL1
Resolution
2.26 Å
R-value
0.186
Predicted activity confidence32.9%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
SRPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVAAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVA
UniProt reference sequence
RGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEK
Aligned reference sequence
RGT---HNFSEE--------LKIGEGG----------------FGCVYRAVM----------------------------------------RNTVYAVKRLK--ENADLEWTAV------------------------KQSFLTEVEQLSRF--------------------------RHPNIVDFAGYCAQNG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FYCLVYGFLPN--------------GSLEDRLHC--QTQACP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSWPQRLDILLGTARAIQFLHQD--SP-----------------------------------------SLIHGDI-----KSSNVLLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLTPKLGDFGLARFSRFAGSS--PSQSSMVART------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QTVRGTLAYLPEEYIKT--------------------------------GRLA-VDTDTFSFGVVVLETLAG-----------------QRAVKT--HGART-------------------------------------------KYLKDLVEEEAEE--AGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELG-----------------------------------------------------------------LGLGQLACCCLHRRAKRRPP--------------MTQVYERLEK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
RGT---HNFSEE--------LKIGEGG----------------FGCVYRAVM----------------------------------------RNTVYAVKRLK-------EWTAV------------------------KQSFLTEVEQLSRF--------------------------RHPNIVDFAGYCAQNG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FYCLVYGFLPN--------------GSLEDRLHC--QTQACP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSWPQRLDILLGTARAIQFLHQD--SP-----------------------------------------SLIHGDI-----KSSNVLLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLTPKLGDFGLARFSR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVRGTLAYLPEEYIKT--------------------------------GRLA-VDTDTFSFGVVVLETLAG-----------------QRAVKT--HGART-------------------------------------------KYLKDLVEEEAEE--AGVA------------AADAWAAPIAMQIYKKHLDPRPGPCPPELG-----------------------------------------------------------------LGLGQLACCCLHRRAKRRPP--------------MTQVYERLEK
Activation segment
DFGLARFSR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVRGTLAYLPEE
Binding pocket
LKIGEGGFGCVYRYAVKRLSFLTEVEQLSRFRPNIVDFAGYCLVYGFLPNGSLEDRLHCHQDSPSLIHGDIKSSNVLLLGDFGLA
Ligand info
Orthosteric ligand
DL1
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6BFN, Chain A