6BDN Chain A
Serine/threonine-protein kinase TAO3 (TAOK3)
Active — 100.0%DFG-inαC-inATPlike · ADP
Resolution
1.5 Å
R-value
0.187
Predicted activity confidence100.0%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
DPEIADLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVRELDNLQYRKMKKILFQ
UniProt reference sequence
FIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFV
Aligned reference sequence
FIGL----------------HEIGHGS----------------FGAVYFATN--AH------------------------------------TSEVVAIKKMS--YSGKQTHEK-------------------------WQDILKEVKFLRQL--------------------------KHPNTIEYKGCYLKEH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAWLVMEYCL---------------GSASDLLEV--HKK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLQEVEIAAITHGALHGLAYLHSH---------------------------------------------ALIHRDI-----KAGNILLTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGQVKLADFGSASMASPA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NSFVGTPYWMAPEVILA--MDE---------------------------GQYD-GKVDIWSLGITCIELAER-----------------KPPLFN--------------------------------------------------MNAMSALYHIAQN--DSPTLQSNEWT----------------------------------------------------------------------------------------------------DSFRRFVDYCLQKIPQERPT--------------SAELLRHDFV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FIGL----------------HEIGHGS----------------FGAVYFATN--AH------------------------------------TSEVVAIKKMS--YSGKQTHEK-------------------------WQDILKEVKFLRQL--------------------------KHPNTIEYKGCYLKEH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAWLVMEYCL---------------GSASDLLEV--HKK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLQEVEIAAITHGALHGLAYLHSH---------------------------------------------ALIHRDI-----KAGNILLTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGQVKLADFGSASMASPA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NSFVGTPYWMAPEVILA--MDE---------------------------GQYD-GKVDIWSLGITCIELAER-----------------KPPLFN--------------------------------------------------MNAMSALYHIAQN--DSPTLQSNEWT----------------------------------------------------------------------------------------------------DSFRRFVDYCLQKIPQERPT--------------SAELLRHDFV
Activation segment
DFGSASMASPA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NSFVGTPYWMAPE
Binding pocket
HEIGHGSFGAVYFVAIKKMDILKEVKFLRQLKPNTIEYKGCWLVMEYCLGSASDLLEVHYLHSHALIHRDIKAGNILLLADFGSA
Ligand info
Orthosteric ligand
ADP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6BDN, Chain A