6AYW Chain B
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D)
Active — 67.8%DFG-inαC-inType1 · C2V
Resolution
2.05 Å
R-value
0.202
Predicted activity confidence67.8%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
CTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRK
UniProt reference sequence
YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI
Aligned reference sequence
YQLF----------------EELGKGA----------------FSVVRRCMK--IP------------------------------------TGQEYAAKIIN--TKKLSARD--------------------------HQKLEREARICRLL--------------------------KHPNIVRLHDSISEEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FHYLVFDLVTG--------------GELFEDIVA--RE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YYSEADASHCIQQILESVNHCHLN---------------------------------------------GIVHRDL-----KPENLLLAS--KSK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GAAVKLADFGLAIEVQGDQQA--W---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGFAGTPGYLSPEVLRK--------------------------------DPYG-KPVDMWACGVILYILLVG-----------------YPPFWD--------------------------------------------------EDQHRLYQQIKAG--AYDFPSPEWDTVT--------------------------------------------------------------------------------------------------PEAKDLINKMLTINPAKRIT--------------ASEALKHPWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YQLF----------------EELGKGA----------------FSVVRRCMK--IP------------------------------------TGQEYAAKIIN--TKKLSARD--------------------------HQKLEREARICRLL--------------------------KHPNIVRLHDSISEEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FHYLVFDLVTG--------------GELFEDIVA--RE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YYSEADASHCIQQILESVNHCHLN---------------------------------------------GIVHRDL-----KPENLLLAS--KSK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GAAVKLADFGLAIEVQGDQQA--W---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGFAGTPGYLSPEVLRK--------------------------------DPYG-KPVDMWACGVILYILLVG-----------------YPPFWD--------------------------------------------------EDQHRLYQQIKAG--AYDFPSPEWDTVT--------------------------------------------------------------------------------------------------PEAKDLINKMLTINPAKRIT--------------ASEALKHPWI
Activation segment
DFGLAIEVQGDQQA--W---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGFAGTPGYLSPE
Binding pocket
EELGKGAFSVVRRYAAKIIKLEREARICRLLKPNIVRLHDSYLVFDLVTGGELFEDIVAHCHLNGIVHRDLKPENLLLLADFGLA
Ligand info
Orthosteric ligand
C2V
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6AYW, Chain B