6AO5 Chain A
Serine/threonine-protein kinase 3 (STK3)
Inactive — 0.4%DFG-inαC-outATPlike · ANP
Resolution
2.95 Å
R-value
0.236
Predicted activity confidence0.4%
Structure info
Alternate conformation—
Missing atoms0
Missing residues1
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
DVLEKLGEGSYGSVFKAIHVVAIKQDLQEIIKEISIMQQCDSPYVVKYYGSYFLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRELEEEENWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDAMDAKKRRQ
UniProt reference sequence
FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFI
Aligned reference sequence
FDVL----------------EKLGEGS----------------YGSVFKAIH--KE------------------------------------SGQVVAIKQVP--VESD------------------------------LQEIIKEISIMQQC--------------------------DSPYVVKYYGSYFKNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLWIVMEYCGA--------------GSVSDIIRL--RNK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLIEDEIATILKSTLKGLEYLHFM---------------------------------------------RKIHRDI-----KAGNILLNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGHAKLADFGVAGQLTDTMAK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTVIGTPFWMAPEVIQE--------------------------------IGYN-CVADIWSLGITSIEMAEG-----------------KPPYAD--------------------------------------------------IHPMRAIFMIPTN--PPPTFRKPELWS---------------------------------------------------------------------------------------------------DDFTDFVKKCLVKNPEQRAT--------------ATQLLQHPFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
-DVL----------------EKLGEGS----------------YGSVFKAIH-------------------------------------------VVAIKQ-------D------------------------------LQEIIKEISIMQQC--------------------------DSPYVVKYYGSYF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LWIVMEYCGA--------------GSVSDIIRL--RNK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLIEDEIATILKSTLKGLEYLHFM---------------------------------------------RKIHRNI-----KAGNILLNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGHAKLADFGVA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VIGTPFWMAPEVIQE--------------------------------IGYN-CVADIWSLGITSIEMAEG-----------------KPPYAD--------------------------------------------------IHPMRAIFMIPTN--PPPTFRKPELWS---------------------------------------------------------------------------------------------------DDFTDFVKKCLVKNPEQRAT--------------ATQLLQHPFI
Activation segment
DFGVA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VIGTPFWMAPE
Binding pocket
EKLGEGSYGSVFKVAIKQ_EIIKEISIMQQCDPYVVKYYGSWIVMEYCGAGSVSDIIRLYLHFMRKIHRNIKAGNILLLADFGVA
Ligand info
Orthosteric ligand
ANP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6AO5, Chain A