6AAM Chain A
Non-receptor tyrosine-protein kinase TYK2 (TYK2)
Inactive — 0.0%DFG-inαC-inType1 · 9T6
Resolution
1.98 Å
R-value
0.204
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues4
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
DPTVFHKRYLKKIRDLGGKVSLYCYDPTNTGEMVAVKALDAGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGLAQGQMTVLRLTELLERGERLPRPDKCPAEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQG
UniProt reference sequence
ITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTR
Aligned reference sequence
ITQL----------------SHLGQGT----------------RTNVYEGRL--RVEGSGDPEEGKMDDEDPLVPGRDRG------------QELRVVLKVLD--PSHHDI----------------------------ALAFYETASLMSQV--------------------------SHTHLAFVHGVCVRGP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ENIMVTEYVEH--------------GPLDVWLRR--ERG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVPMAWKMVVAQQLASALSYLENK---------------------------------------------NLVHGNV-----CGRNILLAR--LGLAEGT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPFIKLSDPGVGLGALSR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EERVERIPWLAPECLPG--GA----------------------------NSLS-TAMDKWGFGATLLEICFD--G--------------EAPLQS--------------------------------------------------RSPSEKEHFYQRQ--HRLPEPSC-------------------------------------------------------------------------------------------------------PQLATLTSQCLTYEPTQRPS--------------FRTILRDLTR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
DPTV----------------FH----K----------------RYLKKIRDL--GGKVSLYCYDPTNTGEMVAVKALDAG------------PQHRSGWK------QEIDI----------------------------LRTLY------------------------------------HEHIIKYKGCCAGAA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLQLVMEYVPL--------------GSLRDYL----PRH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIGLAQLLLFAQQICEGMAYLHAQ---------------------------------------------HYIHRNL-----AARNVLL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNDRLVKIGDFGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKAVPPVFWYAPECL----KE----------------------------YKFY-YASDVWSFGVTLYE---L--L--------------THCDSS--------------------------------------------------QSPPTKTELLERG--ERLPRPDC-------------------------------------------------------------------------------------------------------PAEVYLMKNCWETEASFRPT--------------FKTVHEKYQG
Activation segment
DRLVKIGDFGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKAVPPVFWYAPE
Binding pocket
RDLG____GKVSLVAVKALGWKQEIDILRTLYEHIIKYKGCQLVMEYVPLGSLRDYLPRYLHAQHYIHRNLAARNVLLIGDFGLA
Ligand info
Orthosteric ligand
9T6
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6AAM, Chain A