6A32 Chain A
Platelet-derived growth factor receptor alpha (PDGFRA)
Inactive — 0.2%DFG-outαC-in
Resolution
1.87 Å
R-value
0.205
Predicted activity confidence0.2%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
RYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIIIEYCFYGDLVNYLHKNRDSFLSHKKKSMLDEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSD
UniProt reference sequence
LVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVEN
Aligned reference sequence
LVLG----------------RVLGSGA----------------FGKVVEGTA--YGLSRSQ-------------------------------PVMKVAVKMLK--PTARSSE---------------------------KQALMSELKIMTHL--G-----------------------PHLNIVNLLGACTKSG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIITEYCFY--------------GDLVNYLHK--NRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLTLLDLLSFTYQVARGMEFLASK---------------------------------------------NCVHRDL-----AARNVLLAQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKIVKICDFGLARDIMHDSNY--VSK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSTFLPVKWMAPESIFD--------------------------------NLYT-TLSDVWSYGILLWEIFSL--G--------------GTPYPG--M-----------------------------------------------MVDSTFYNKIKSG--YRMAKPDHAT-----------------------------------------------------------------------------------------------------SEVYEIMVKCWNSEPEKRPS--------------FYHLSEIVEN
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LVLG----------------RVLGSGA----------------FGKVVEGTA--YGLSRSQ-------------------------------PVMKVAVKMLK--PTARSSE---------------------------KQALMSELKIMTHL--G-----------------------PHLNIVNLLGACTKSG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIIIEYCFY--------------GDLVNYLHK--NRDSFLSH------------------------------------------------------------------------KKKSMLD------------E-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLTLLDLLSFTYQVARGMEFLASK---------------------------------------------NCVHRDL-----AARNVLLAQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKIVKICDFGLARDIMHDSNY--VSK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSTFLPVKWMAPESIFD--------------------------------NLYT-TLSDVWSYGILLWEIFSL--G--------------GTPYPG--M-----------------------------------------------MVDSTFYNKIKSG--YRMAKPDHAT-----------------------------------------------------------------------------------------------------SEVYEIMVKCWNSEPEKRPS--------------FYHLSEIVEN
Activation segment
DFGLARDIMHDSNY--VSK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSTFLPVKWMAPE
Binding pocket
RVLGSGAFGKVVEVAVKMLALMSELKIMTHLGLNIVNLLGAYIIIEYCFYGDLVNYLHKFLASKNCVHRDLAARNVLLICDFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6A32, Chain A