5YVB Chain A
Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2)
Active — 100.0%DFG-inαC-inType1 · 92C
Resolution
2.02 Å
R-value
0.172
Predicted activity confidence100.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
VQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTR
UniProt reference sequence
YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV
Aligned reference sequence
YTLK----------------DEIGKGS----------------YGVVKLAYN--EN------------------------------------DNTYYAMKVLS--KKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGP--IEQVYQEIAILKKL--------------------------DHPNVVKLVEVLDDPN--ED----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLYMVFELVNQ--------------GPVMEVPTL--K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSEDQARFYFQDLIKGIEYLHYQ---------------------------------------------KIIHRDI-----KPSNLLVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGHIKIADFGVSNEFKGSDAL--L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNTVGTPAFMAPESLSE--TR----------------------------KIFSGKALDVWAMGVTLYCFVFG-----------------QCPFMD--------------------------------------------------ERIMCLHSKIKSQ--ALEFPDQPDIA----------------------------------------------------------------------------------------------------EDLKDLITRMLDKNPESRIV--------------VPEIKLHPWV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YTLK----------------DEIGKGS----------------YGVVKLAYN--EN------------------------------------DNTYYAMKVLS--KK-----------------------------P--IEQVYQEIAILKKL--------------------------DHPNVVKLVEVLDDPN--ED----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLYMVFELVNQ--------------GPVMEVPTL--K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSEDQARFYFQDLIKGIEYLHYQ---------------------------------------------KIIHRDI-----KPSNLLVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGHIKIADFGVSNEFKGSDAL--L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNTVGTPAFMAPESLSE--TR----------------------------KIFSGKALDVWAMGVTLYCFVFG-----------------QCPFMD--------------------------------------------------ERIM-LHSKIKSQ--ALEFPDQPDIA----------------------------------------------------------------------------------------------------EDLKDLITRMLDKNPESRIV--------------VPEIKLHPWV
Activation segment
DFGVSNEFKGSDAL--L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNTVGTPAFMAPE
Binding pocket
DEIGKGSYGVVKLYAMKVLQVYQEIAILKKLDPNVVKLVEVYMVFELVNQGPVMEVPTLYLHYQKIIHRDIKPSNLLVIADFGVS
Ligand info
Orthosteric ligand
92C
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5YVB, Chain A