5YKS Chain A
SNF-related serine/threonine-protein kinase (SNRK)
Inactive — 0.0%DFG-inαC-out
Resolution
2.9 Å
R-value
0.224
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms5
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
HSQDLEVLFQGPHMGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDAIVEALETNRYNHITATYFLLAERILREKQEKE
UniProt reference sequence
YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWL
Aligned reference sequence
YDLD----------------KTLGRGH----------------FAVVKLARH--VF------------------------------------TGEKVAVKVID--KTKLDTLA--------------------------TGHLFQEVRCMKLV--------------------------QHPNIVRLYEVIDTQT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLYLILELGDG--------------GDMFDYIMK--HEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLNEDLAKKYFAQIVHAISYCHKL---------------------------------------------HVVHRDL-----KPENVVFFE--K-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGLVKLTDFGFSNKFQPGKKL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTSCGSLAYSAPEILLG--------------------------------DEYDAPAVDIWSLGVILFMLVCG-----------------QPPFQE--------------------------------------------------ANDSETLTMIMDC--KYTVPSHVS------------------------------------------------------------------------------------------------------KECKDLITRMLQRDPKRRAS--------------LEEIENHPWL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
EVLF----------------QGPHMGH----------------FAVVKLARH--VF------------------------------------TGEKVAVKVID--KTKLDTLA--------------------------TGHLFQEVRCMKLV--------------------------QHPNIVRLYEVIDTQT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLYLILELGDG--------------GDMFDYIMK--HEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLNEDLAKKYFAQIVHAISYCHKL---------------------------------------------HVVHRDL-----KPENVVFFE--K-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGLVKLTDFGF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLAYSAPEILLG--------------------------------DEYDAPAVDIWSLGVILFMLVCG-----------------QPPFQE--------------------------------------------------ANDSETLTMIMDC--KYTVPSHVS------------------------------------------------------------------------------------------------------KECKDLITRMLQRDPKRRAS--------------LEEIENHPWL
Activation segment
DFGF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLAYSAPE
Binding pocket
QGPHMGHFAVVKLVAVKVIHLFQEVRCMKLVQPNIVRLYEVYLILELGDGGDMFDYIMKYCHKLHVVHRDLKPENVVFLTDFGFS
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5YKS, Chain A