5Y86 Chain A
Dual specificity tyrosine-phosphorylation-regulated kinase 3 (DYRK3)
Active — 91.2%DFG-inαC-inType1 · HRM
Resolution
1.9 Å
R-value
0.168
Predicted activity confidence91.2%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
VVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSTKVIDFGSSCFEYQKLYTIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLPAQALRHPWISKSVPRPLTT
UniProt reference sequence
YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI
Aligned reference sequence
YEVL----------------KIIGKGS----------------FGQVARVYD--HK------------------------------------LRQYVALKMVR--NEKRF-----------------------------HRQAAEEIRILEHL--KKQDKT------------------GSMNVIHMLESFTFRN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVCMAFELLS---------------IDLYELIKK--NKFQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GFSVQLVRKFAQSILQSLDALHKN---------------------------------------------KIIHCDL-----KPENILLKH--HG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSSTKVIDFGSSCFEYQKL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YTYIQSRFYRAPEIILG--------------------------------SRYS-TPIDIWSFGCILAELLTG-----------------QPLFPG--------------------------------------------------EDEGDQLACMMEL--LGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD-------------------------------------------YLFIEFLKRCLHWDPSARLT--------------PAQALRHPWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEVL----------------KIIGKGS----------------FGQVARVYD--HK------------------------------------LRQYVALKMVR--NEKRF-----------------------------HRQAAEEIRILEHL--KKQDKT------------------GSMNVIHMLESFTFRN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVCMAFELLS---------------IDLYELIKK--NKFQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GFSVQLVRKFAQSILQSLDALHKN---------------------------------------------KIIHCDL-----KPENILLKH--HG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R-STKVIDFGSSCFEYQKL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YT-IQSRFYRAPEIILG--------------------------------SRYS-TPIDIWSFGCILAELLTG-----------------QPLFPG--------------------------------------------------EDEGDQLACMMEL--LGMPPPKLLEQSKRAKYFIN-KGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD-------------------------------------------YLFIEFLKRCLHWDPSARL---------------PAQALRHPWI
Activation segment
DFGSSCFEYQKL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YT-IQSRFYRAPE
Binding pocket
KIIGKGSFGQVARVALKMVQAAEEIRILEHLKMNVIHMLESCMAFELLS_IDLYELIKKALHKNKIIHCDLKPENILLVIDFGSS
Ligand info
Orthosteric ligand
HRM
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5Y86, Chain A