5Y80 Chain A
Cyclin-G-associated kinase (GAK)
Active — 100.0%DFG-inαC-inType1,Allosteric · IRE
Resolution
2.5 Å
R-value
0.232
Predicted activity confidence100.0%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
SQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAARNVNPKSPITELL
UniProt reference sequence
LRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQE
Aligned reference sequence
LRVR----------------RVLAEGG----------------FAFVYEAQD--VG------------------------------------SGREYALKRLL--SNEEEK----------------------------NRAIIQEVCFMKKL--S-----------------------GHPNIVQFCSAASIGK--EESDTGQA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFLLLTELCK---------------GQLVEFLKK--MESRG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSCDTVLKIFYQTCRAVQHMHRQ--KP-----------------------------------------PIIHRDL-----KVENLLLSN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGTIKLCDFGSATTISHYPDY--SWSAQRRALVEEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ITRNTTPMYRTPEIIDL--YSN---------------------------FPIG-EKQDIWALGCILYLLCFR-----------------QHPFED------------------------------------------------------GAKLRIVNG--KYSIPPHDTQY----------------------------------------------------------------------------------------------------TVFHSLIRAMLQVNPEERLS--------------IAEVVHQLQE
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LRVR----------------RVLAEGG----------------FAFVYEAQD--VG------------------------------------SGREYALKRLL--SNEEEK----------------------------NRAIIQEVCFMKKL--S-----------------------GHPNIVQFCSAASIGK--EESDTGQA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFLLLTELCK---------------GQLVEFLKK--M---G----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSCDTVLKIFYQTCRAVQHMHRQ--KP-----------------------------------------PIIHRDL-----KVENLLLSN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGTIKLCDFGSATTISHYPDY--SWSAQRRALVEEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ITRNTTPMYRTPEIIDL--YSN---------------------------FPIG-EKQDIWALGCILYLLCFR-----------------QHPFED------------------------------------------------------GAKLRIVNG--KYSIPPHDTQY----------------------------------------------------------------------------------------------------TVFHSLIRAMLQVNPEERLS--------------IAEVVHQLQE
Activation segment
DFGSATTISHYPDY--SWSAQRRALVEEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ITRNTTPMYRTPE
Binding pocket
RVLAEGGFAFVYEYALKRLAIIQEVCFMKKLSPNIVQFCSALLLTELCK_GQLVEFLKKHRQKPPIIHRDLKVENLLLLCDFGSA
Ligand info
Orthosteric ligand
IRE
Allosteric ligand
IRE
Ligand typeType1,Allosteric
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5Y80, Chain A