5WVD Chain A
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)
Inactive — 2.0%DFG-outαC-inType1 · 7UX
Resolution
3.0 Å
R-value
0.242
Predicted activity confidence2.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
PGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQ
UniProt reference sequence
YKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV
Aligned reference sequence
YKLT--S-------------ELLGEGA----------------YAKVQGAVS--LQ------------------------------------NGKEYAVKIIE--KQAGHS----------------------------RSRVFREVETLYQC--Q-----------------------GNKNILELIEFFEDDT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFYLVFEKLQG--------------GSILAHIQK--QK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HFNEREASRVVRDVAAALDFLHTK--DKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTT--GIAHRDL-----KPENILCES--PEK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VSPVKICDFDLGSGMKLNNSC--TPITTPEL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTPCGSAEYMAPEVVEV--FTDQA-------------------------TFYD-KRCDLWSLGVVLYIMLSG-----------------YPPFVG--HCGADCGWDRGEVCR---------------------------------VCQNKLFESIQEG--KYEFPDKDWAHIS--------------------------------------------------------------------------------------------------SEAKDLISKLLVRDAKQRLS--------------AAQVLQHPWV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YKLT--S-------------ELLGEGA----------------YAKVQGAVS--LQ------------------------------------NGKEYAVKIIE--KQAGHS----------------------------RSRVFREVETLYQC--Q-----------------------GNKNILELIEFFEDDT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFYLVFEKLQG--------------GSILAHIQK--QK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HFNEREASRVVRDVAAALDFLHTK---------------------------------------------GIAHRDL-----KPENILCES--PEK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VSPVKICDFDLGSG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YMAPEVVEV--FTDQA-------------------------TFYD-KRCDLWSLGVVLYIMLSG-----------------YPPF-------------------------------------------------------------------KYEFPDKDWAHIS--------------------------------------------------------------------------------------------------SEAKDLISKLLVRDAKQRLS--------------AAQVLQHPWV
Activation segment
DFDLGSG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YMAPE
Binding pocket
ELLGEGAYAKVQGYAVKIIRVFREVETLYQCQKNILELIEFYLVFEKLQGGSILAHIQKFLHTKGIAHRDLKPENILCICDFDLG
Ligand info
Orthosteric ligand
7UX
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5WVD, Chain A