5WNK Chain A
Receptor-interacting serine/threonine-protein kinase 4 (RIPK4)
Inactive — 1.8%DFG-inαC-inType1.5_Back · B6J
Resolution
3.11 Å
R-value
0.228
Predicted activity confidence1.8%
Structure info
Alternate conformation—
Missing atoms46
Missing residues2
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
ALGLLRTFDAGEFAGWEKVGSFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVYGICQEPVGLVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVKGHRPELPPICRPRPRACASLIGLMQRCWHADPQVRPTFQEITSETEDLCE
UniProt reference sequence
FTGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVYGICREPVGLVMEYMETGSLEKLLASEPLPWDLRFRIIHETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSHSHDLSMDGLFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMVKVVKGHRPELPPVCRARPRACSHLIRLMQRCWQGDPRVRPTFQGNGLNGEL
Aligned reference sequence
FTGW----------------EKVGSGG----------------FGQVYKVRH--VH------------------------------------WKTWLAIKCSP--SLHVDDRE--------------------------RMELLEEAKKMEMA--------------------------KFRYILPVYGICRE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVGLVMEYMET--------------GSLEKLLAS--E--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLPWDLRFRIIHETAVGMNFLHCM--AP-----------------------------------------PLLHLDL-----KPANILLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HYHVKISDFGLAKCNGLSHSH--DLSM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGLFGTIAYLPPERIRE--KS----------------------------RLFD-TKHDVYSFAIVIWGVLTQ-----------------KKPFAD--E-----------------------------------------------KNILHIMVKVVKG--HRPELPPVCRARPRAC-----------------------------------------------------------------------------------------------SHLIRLMQRCWQGDPRVRPT--------------FQGNGLNGEL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FAGW----------------EKVGS------------------FGQVYKVRH--VH------------------------------------WKTWLAIKCSP--SLHVDDRE--------------------------RMELLEEAKKMEMA--------------------------KFRYILPVYGICQE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVGLVMEYMET--------------GSLEKLLAS--E--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLPWDLRFRIVHETAVGMNFLHCM--SP-----------------------------------------PLLHLNL-----KPANILLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HYHVKISDFGLAKC----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGTIAYLPPERIRE--KS----------------------------RLFD-TKHDVYSFAIVIWGVLTQ-----------------KKPFAD--E-----------------------------------------------KNILHIMMKVVKG--HRPELPPICRPRPRAC-----------------------------------------------------------------------------------------------ASLIGLMQRCWHADPQVRPT--------------FQEITSETEE
Activation segment
DFGLAKC----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGTIAYLPPE
Binding pocket
EKVGS__FGQVYKLAIKCSELLEEAKKMEMAKRYILPVYGIGLVMEYMETGSLEKLLASHCMSPPLLHLNLKPANILLISDFGLA
Ligand info
Orthosteric ligand
B6J
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5WNK, Chain A