5WNJ Chain A
Receptor-interacting serine/threonine-protein kinase 4 (RIPK4)
Inactive — 1.4%DFG-inαC-inType1 · 2V9
Resolution
2.55 Å
R-value
0.221
Predicted activity confidence1.4%
Structure info
Alternate conformation—
Missing atoms30
Missing residues2
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
ALGLLRTFDAGEFAGWEKVGSFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVYGICQEPVGLVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVKGHRPELPPICRPRPRACASLIGLMQRCWHADPQVRPTFQEITSETEDLCEK
UniProt reference sequence
FTGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVYGICREPVGLVMEYMETGSLEKLLASEPLPWDLRFRIIHETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSHSHDLSMDGLFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMVKVVKGHRPELPPVCRARPRACSHLIRLMQRCWQGDPRVRPTFQGNGLNGEL
Aligned reference sequence
FTGW----------------EKVGSGG----------------FGQVYKVRH--VH------------------------------------WKTWLAIKCSP--SLHVDDRE--------------------------RMELLEEAKKMEMA--------------------------KFRYILPVYGICRE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVGLVMEYMET--------------GSLEKLLAS--E--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLPWDLRFRIIHETAVGMNFLHCM--AP-----------------------------------------PLLHLDL-----KPANILLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HYHVKISDFGLAKCNGLSHSH--DLSM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGLFGTIAYLPPERIRE--KS----------------------------RLFD-TKHDVYSFAIVIWGVLTQ-----------------KKPFAD--E-----------------------------------------------KNILHIMVKVVKG--HRPELPPVCRARPRAC-----------------------------------------------------------------------------------------------SHLIRLMQRCWQGDPRVRPT--------------FQGNGLNGEL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FAGW----------------EKVGS------------------FGQVYKVRH--VH------------------------------------WKTWLAIKCSP--SLHVDDRE--------------------------RMELLEEAKKMEMA--------------------------KFRYILPVYGICQE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVGLVMEYMET--------------GSLEKLLAS--E--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLPWDLRFRIVHETAVGMNFLHCM--SP-----------------------------------------PLLHLNL-----KPANILLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HYHVKISDFGLAKC----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGTIAYLPPERIRE--KS----------------------------RLFD-TKHDVYSFAIVIWGVLTQ-----------------KKPFAD--E-----------------------------------------------KNILHIMMKVVKG--HRPELPPICRPRPRAC-----------------------------------------------------------------------------------------------ASLIGLMQRCWHADPQVRPT--------------FQETEDLCEK
Activation segment
DFGLAKC----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGTIAYLPPE
Binding pocket
EKVGS__FGQVYKLAIKCSELLEEAKKMEMAKRYILPVYGIGLVMEYMETGSLEKLLASHCMSPPLLHLNLKPANILLISDFGLA
Ligand info
Orthosteric ligand
2V9
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5WNJ, Chain A