5WNI Chain A
Receptor-interacting serine/threonine-protein kinase 4 (RIPK4)
Inactive — 5.6%DFG-inαC-inATPlike · ATP
Resolution
2.65 Å
R-value
0.204
Predicted activity confidence5.6%
Structure info
Alternate conformation—
Missing atoms13
Missing residues4
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
WALGLLRTFDAGEFAGWEKVGSQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVYGICQEPVGLVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVKGHRPELPPICRPRPRACASLIGLMQRCWHADPQVRPTFQEITSETEDLCE
UniProt reference sequence
FTGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVYGICREPVGLVMEYMETGSLEKLLASEPLPWDLRFRIIHETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSHSHDLSMDGLFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMVKVVKGHRPELPPVCRARPRACSHLIRLMQRCWQGDPRVRPTFQGNGLNGEL
Aligned reference sequence
FTGW----------------EKVGSGG----------------FGQVYKVRH--VH------------------------------------WKTWLAIKCSP--SLHVDDRE--------------------------RMELLEEAKKMEMA--------------------------KFRYILPVYGICRE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVGLVMEYMET--------------GSLEKLLAS--E--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLPWDLRFRIIHETAVGMNFLHCM--AP-----------------------------------------PLLHLDL-----KPANILLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HYHVKISDFGLAKCNGLSHSH--DLSM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGLFGTIAYLPPERIRE--KS----------------------------RLFD-TKHDVYSFAIVIWGVLTQ-----------------KKPFAD--E-----------------------------------------------KNILHIMVKVVKG--HRPELPPVCRARPRAC-----------------------------------------------------------------------------------------------SHLIRLMQRCWQGDPRVRPT--------------FQGNGLNGEL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FAGW----------------EKVGS--------------------QVYKVRH--VH------------------------------------WKTWLAIKCSP--SLHVDDRE--------------------------RMELLEEAKKMEMA--------------------------KFRYILPVYGICQE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVGLVMEYMET--------------GSLEKLLAS--E--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLPWDLRFRIVHETAVGMNFLHCM--SP-----------------------------------------PLLHLNL-----KPANILLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HYHVKISDFGLAKCN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGTIAYLPPERIRE--KS----------------------------RLFD-TKHDVYSFAIVIWGVLTQ-----------------KKPFAD--E-----------------------------------------------KNILHIMMKVVKG--HRPELPPICRPRPRAC-----------------------------------------------------------------------------------------------ASLIGLMQRCWHADPQVRPT--------------FQEITSETEE
Activation segment
DFGLAKCN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGTIAYLPPE
Binding pocket
EKVGS____QVYKLAIKCSELLEEAKKMEMAKRYILPVYGIGLVMEYMETGSLEKLLASHCMSPPLLHLNLKPANILLISDFGLA
Ligand info
Orthosteric ligand
ATP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5WNI, Chain A