5WFJ Chain A
Tyrosine-protein kinase JAK3 (JAK3)
Inactive — 3.9%DFG-inαC-inType1 · 9Z4
Resolution
2.48 Å
R-value
0.205
Predicted activity confidence3.9%
Structure info
Alternate conformation—
Missing atoms0
Missing residues4
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
FEERHLKYISQLGGSVELCRYDPLGDNTGALVAVKQLQPDQQRDFQREIQILKALHSDFIVKYRGVSYGPLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMVPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLW
UniProt reference sequence
LEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNS
Aligned reference sequence
LEWH----------------ENLGHGS----------------FTKIYRGCR--HEVVDGEA------------------------------RKTEVLLKVMD--AKHKNC----------------------------MESFLEAASLMSQV--------------------------SYRHLVLLHGVCMAG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSTMVQEFVHL--------------GAIDMYLRK--RGH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVPASWKLQVVKQLAYALNYLEDK---------------------------------------------GLPHGNV-----SARKVLLAR--EGADGS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPFIKLSDPGVSPAVLSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMLTDRIPWVAPECLRE--A-----------------------------QTLS-LEADKWGFGATVWEVFSG--V--------------TMPISA--------------------------------------------------LDPAKKLQFYEDR--QQLPAPKW-------------------------------------------------------------------------------------------------------TELALLIQQCMAYEPVQRPS--------------FRAVIRDLNS
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FEER----------------HLKYISQ----------------LGGSVELCR-----YDPLG------------------------------DNTGALVAVKQ--LQPDQQ----------------------------RDFQREIQILKALH--------------------------S-DFIVKYRGV-SYG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLRLVMEYLPS--------------GCLRDFLQR--HRA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLDASRLLLYSSQICKGMEYLGSR---------------------------------------------RCVHRDL-----AARHVKIAD--FGLAKL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPLDKYVVPGQSP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IFWYAPESL-S--D-----------------------------NIFS-RQSDVWSFGVVLYELFEF--L--------------RMMVPA--------------------------------------------------L--SRLLELLEEG--QRLPAPCP-------------------------------------------------------------------------------------------------------AEVHELMKLCWAPSPQDRPS--------------FSAPQLDMLW
Activation segment
VPGQSP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IFWYAPE
Binding pocket
SQLG____GSVELVAVKQLDFQREIQILKALHDFIVKYRGVRLVMEYLPSGCLRDFLQRYLGSRRCVHRDLAARNILVIADFGLA
Ligand info
Orthosteric ligand
9Z4
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5WFJ, Chain A