5W5V Chain A
Serine/threonine-protein kinase TBK1 (TBK1)
Inactive — 0.1%DFG-inαC-outType1 · ANW
Resolution
3.64 Å
R-value
0.235
Predicted activity confidence0.1%
Structure info
Alternate conformation—
Missing atoms0
Missing residues6
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
MQSTSNHLWLLSDILTANVFRGRHKKTGDLFAIKVFVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGEEYLHPDMYERATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILDQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVLEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVKVEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQET
UniProt reference sequence
HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSD
Aligned reference sequence
HLWL--LS------------DILGQGA----------------TANVFRGRH--KK------------------------------------TGDLFAIKVFN--NISFLRP---------------------------VDVQMREFEVLKKL--------------------------NHKNIVKLFAIEEETT--TR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HKVLIMEFCPC--------------GSLYTVLEE--PSNAY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPESEFLIVLRDVVGGMNHLREN---------------------------------------------GIVHRDI-----KPGNIMRVI--GEDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSVYKLTDFGAARELEDDEQF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VSLYGTEEYLHPDMYER--AVLRKDHQ----------------------KKYG-ATVDLWSIGVTFYHAATG-----------------SLPFRP--FEGPR-------------------------------------------RNKEVMYKIITGK--PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQ------------------------------------------------------------------------------VLLTPVLANILEADQEKCWG--------------FDQFFAETSD
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
HLWL--LS------------DIL--------------------TANVFRGRH--KK------------------------------------TGDLFAIKVF-------------------------------------VDVQMREFEVLKKL--------------------------NHKNIVKLFAIEEETT--TR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HKVLIMEFCPC--------------GSLYTVLEE--PSNAY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPESEFLIVLRDVVGGMNHLREN---------------------------------------------GIVHRDI-----KPGNIMRVI--GEDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSVYKLTDFG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEYLHPDMYER-------------------------------------ATVDLWSIGVTFYHAATG-----------------SLPFRP--FEGPR-------------------------------------------RNKEVMYKIITGK--PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQ------------------------------------------------------------------------------VLLTPVLANIL--DQEKCWG--------------FDQFFAETSD
Activation segment
DFG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEYLHPD
Binding pocket
DIL____TANVFRFAIKVFVQMREFEVLKKLNKNIVKLFAIVLIMEFCPCGSLYTVLEPHLRENGIVHRDIKPGNIMRLTDFG__
Ligand info
Orthosteric ligand
ANW
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5W5V, Chain A