5W5Q Chain B
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)
Inactive — 0.1%DFG-outαC-out
Resolution
2.33 Å
R-value
0.211
Predicted activity confidence0.1%
Structure info
Alternate conformationB
Missing atoms0
Missing residues2
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
IDLSSLRDPAGIFELVEVVGNGGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRK
UniProt reference sequence
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI
Aligned reference sequence
FELV----------------EVVGNGT----------------YGQVYKGRH--VK------------------------------------TGQLAAIKVMD--VTEDE-----------------------------EEEIKLEINMLKKY--S-----------------------HHRNIATYYGAFIKKS--PPGHDD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLVMEFCGA--------------GSITDLVKN--TKGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLKEDWIAYISREILRGLAHLHIH---------------------------------------------HVIHRDI-----KGQNVLLTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAEVKLVDFGVSAQLDRTVGR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFIGTPYWMAPEVIAC--DENPD-------------------------ATYD-YRSDLWSCGITAIEMAEG-----------------APPLCD--------------------------------------------------MHPMRALFLIPRN--PPPRLKSKKWS----------------------------------------------------------------------------------------------------KKFFSFIEGCLVKNYMQRPS--------------TEQLLKHPFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FELV----------------EVVGNG------------------GQVYKGRH--VK------------------------------------TGQLAAIKVMD--VTEDE-----------------------------EEEIKLEINMLKKY--S-----------------------HHRNIATYYGAFIKKS--PPGHDD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLVMEFCGA--------------GSITDLVKN--TKGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLKEDWIAYISREILRGLAHLHIH---------------------------------------------HVIHRDI-----KGQNVLLTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAEVKLVDFGVSAQLDRTVGR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFIGTPYWMAPEVIAC--DENPD-------------------------ATYD-YRSDLWSCGITAIEMAEG-----------------APPLCD--------------------------------------------------MHPMRALFLIPRN--PPPRLKSKKWS----------------------------------------------------------------------------------------------------KKFFSFIEGCLVKNYMQRPS--------------TEQLLKHPFI
Activation segment
DFGVSAQLDRTVGR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFIGTPYWMAPE
Binding pocket
EVVGNG__GQVYKAAIKVMEIKLEINMLKKYSRNIATYYGAWLVMEFCGAGSITDLVKNHLHIHHVIHRDIKGQNVLLLVDFGVS
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5W5Q, Chain B