5W5J Chain B
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)
Inactive — 1.7%DFG-outαC-outType1 · 9WS
Resolution
2.85 Å
R-value
0.22
Predicted activity confidence1.7%
Structure info
Alternate conformation—
Missing atoms42
Missing residues6
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
LPTIPYHKLADLRYLSRASGTVSSARHADWRVQVAVKHLHDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPHHDLKTQNILLDNEFHVKIADFTIIYMPPENYEIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKK
UniProt reference sequence
LADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEP
Aligned reference sequence
LADL----------------RYLSRGA----------------SGTVSSARH--AD------------------------------------WRVQVAVKHLH--IHTPLLDSE-------------------------RKDVLREAEILHKA--------------------------RFSYILPILGICNEPE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLGIVTEYMPN--------------GSLNELLHR--KTEYP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVAWPLRFRILHEIALGVNYLHNM--TP-----------------------------------------PLLHHDL-----KTQNILLDN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFHVKIADFGLSKWRMMSLSQ--SRSSKS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APEGGTIIYMPPENYEP--GQK---------------------------SRAS-IKHDIYSYAVITWEVLSR-----------------KQPFED--V-----------------------------------------------TNPLQIMYSVSQG--HRPVINEESLPYDIPHR----------------------------------------------------------------------------------------------ARMISLIESGWAQNPDERPS--------------FLKCLIELEP
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LADL----------------RYLSR-A----------------SGTVSSARH--AD------------------------------------WRVQVAVKHLH--------------------------------------DVLREAEILHKA--------------------------RFSYILPILGICNEPE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLGIVTEYMPN--------------GSLNELLHR--KTEYP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVAWPLRFRILHEIALGVNYLHNM--TP-----------------------------------------P--HHDL-----KTQNILLDN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFHVKIADF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIIYMPPENYE--------------------------------------IKHDIYSYAVITWEVLSR-----------------KQPFED--V-----------------------------------------------TNPLQIMYSVSQG--HRPVINEESLPYDIPHR----------------------------------------------------------------------------------------------ARMISLIESGWAQNPDERPS--------------FLKCLIELEP
Activation segment
DF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIIYMPPE
Binding pocket
RYLSR_ASGTVSSVAVKHLDVLREAEILHKARSYILPILGIGIVTEYMPNGSLNELLHRHNMTPP__HHDLKTQNILLIADF___
Ligand info
Orthosteric ligand
9WS
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5W5J, Chain B