5VJA Chain D
Death-associated protein kinase 3 (DAPK3)
Active — 99.4%DFG-inαC-inType1 · DUK
Resolution
2.46 Å
R-value
0.19
Predicted activity confidence99.4%
Structure info
Alternate conformationA
Missing atoms0
Missing residues3
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
SMVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSVSREEIEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKA
UniProt reference sequence
YEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWI
Aligned reference sequence
YEMG----------------EELGSGQ----------------FAIVRKCRQ--KG------------------------------------TGKEYAAKFIK--KRRLSSSRRGVS----------------------REEIEREVNILREI--------------------------RHPNIITLHDIFENKT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVVLILELVSG--------------GELFDFLAE--KE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLTEDEATQFLKQILDGVHYLHSK---------------------------------------------RIAHFDL-----KPENIMLLD--KNVP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPRIKLIDFGIAHKIEAGNEF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNIFGTPEFVAPEIVNY--------------------------------EPLG-LEADMWSIGVITYILLSG-----------------ASPFLG--------------------------------------------------ETKQETLTNISAV--NYDFDEEYFSNTS--------------------------------------------------------------------------------------------------ELAKDFIRRLLVKDPKRRMT--------------IAQSLEHSWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEMG----------------EELGSGQ----------------FAIVRKCRQ--KG------------------------------------TGKEYAAKFIK--KRRLS-----VS----------------------REEIEREVNILREI--------------------------RHPNIITLHDIFENKT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVVLILELVSG--------------GELFD---E--KE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLTEDEATQFLKQILDGVHYLHSK---------------------------------------------RIAHFDL-----KPENIMLLD----VP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPRIKLIDFGIAHKIEAGNEF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNIFGTPEFVAPEIVNY--------------------------------EPLG-LEADMWSIGVITYILLSG-----------------ASPFLG--------------------------------------------------ETKQETLTNISAV--NYDFDEEYFSNTS--------------------------------------------------------------------------------------------------ELAKDFIRRLLVKDPKRRMT--------------IAQSLEHSWI
Activation segment
DFGIAHKIEAGNEF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNIFGTPEFVAPE
Binding pocket
EELGSGQFAIVRKYAAKFIEIEREVNILREIRPNIITLHDIVLILELVSGGELFD___EYLHSKRIAHFDLKPENIMLLIDFGIA
Ligand info
Orthosteric ligand
DUK
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5VJA, Chain D