5VE6 Chain A
Inactive tyrosine-protein kinase PRAG1 (SGK223)
Inactive — 31.6%DFG-outαC-out
Resolution
2.95 Å
R-value
0.222
Predicted activity confidence31.6%
Structure info
Alternate conformation—
Missing atoms0
Missing residues22
Salt bridge (KinCore)Saltbr-na
Sequence info
PDB sequence
NISSKEGTYAKLGGLYTQSLARLVAKCEDLFMGFNENNWSLFKLTCNKPCCDSGDAIYYCATCSEDPGSTYAVKICKAPSVPVHFNIQQDCGHFVASVPSSMLSAQEQDCVVVITREVPHQTASDFVRDSAASHQAEPEAYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCTLQLPRLIISNFLAPEIVSASQYRKFDEFQTGILIYELLHQPNPFEVRAQLRERDYRQEDLPPLPALSLYSPGLQQLAHLLLEADPIKRIRIGEAKRVLQCLLWGPRREALCGTLHNWIDMKRALMMMKFAEKAVDRRRGVELEDWLCCQYLASAEPGALLQSLKLLQL
UniProt reference sequence
FKLTCNKPCCDSGDAIYYCATCSEDPGSTYAVKICKAPEPKTVSYCSPSVPVHFNIQQDCGHFVASVPSSMLSSPDAPKDPVPALPTHPPAQEQDCVVVITREVPHQTASDFVRDSAASHQAEPEAYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCTLQAGPGPAPAPAPAPAPAAAAPPCSSAAPPAGGTLSPAAGPASPEGPREKQLPRLIISNFLKAKQKPGGTPNLQQKKSQARLAPEIVSASQYRKFDEFQTGILIYELLHQPNPFEVRAQLRERDYRQEDLPPLPALSLYSPGLQQLAHLLLEADPIKRIRIGEAKRVLQC
Aligned reference sequence
—
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
—
Activation segment
—
Binding pocket
SVPVHFNIQQDCGSMLSAQ______________________VITREVPHQTASDFVRDSHLKEHGIIHRDLCLENLLLPRLIISN
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5VE6, Chain A